Selective, cell-permeable mitochondrial division Drp1 inhibitor (IC 50 = 10 μM). Inhibits mitochondrial outer membrane permeabilization to prevent apoptosis in vitro . Anti-stroke and neuroprotective agent. Active in vivo and in vitro.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This compound belongs to the class of organic compounds known as quinazolines. These are compounds containing a quinazoline moiety, which is made up of two fused six-member aromatic rings, a benzene ring and a pyrimidine ring.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
1.Yan Xiao-dan, Fan Rong-hua, Wang Yu, Duan Xiao-xu, Wei Xuan, Li Lin-sen, Yu Qing. (2025) α-asarone activates mitophagy to relieve diabetic encephalopathy via inhibiting apoptosis and oxidative stress. METABOLIC BRAIN DISEASE, 40 (2):(1-16). [PMID:39954135][10.1007/s11011-025-01556-3]
2.Hao Ling, Chunli Song. (2025) Oleuropein Modulates Mitophagy and Metabolism in Cardiomyocyte Via the PINK1/Parkin Signaling Pathway. DRUG DEVELOPMENT RESEARCH, 86 (7):(e70171). [PMID:41001689][10.1002/ddr.70171]
3.Hao Ling, Yu Zhang, Chunli Song. (2025) Chlorogenic acid modulates mitochondrial damage and mitophagy to repair injured myocardial tissue and cells. Frontiers in Pharmacology, [PMID:41104339][10.3389/fphar.2025.1658090]
4.Hao Ling, Annan Liu, Yu Zhang, Quan Lin, Chunli Song. (2026) Biomimetic Selenium-Encrusted Prussian Blue Nanozyme for Myocardial Infarction by Coordinated Enhancement of Mitophagy and Reactive Oxygen Species Scavenging. ACS Nano, [PMID:41665146][10.1021/acsnano.5c17071]
5.Yu Jia-Xin, Zhang Wen-Xuan, Li Pu-Yu, Yang Yi-Liang, Huang Han-Chang. (2026) Curcumin Rescues Oxidative Stress-Induced Impairment of PINK1/Parkin Pathway-Mediated Mitophagy in APOE4-Expressing Astrocytes. MOLECULAR NEUROBIOLOGY, 63 (1):(454). [PMID:41706344][10.1007/s12035-026-05744-9]
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I2215322