10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 5 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Mdivi-1 Mdivi-1 (Mitochondrial division inhibitor 1) is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. Mdivi-1 attenuates mitophagy and enhan
In vitro
Mdivi-1 is a cell-permeable quinazolinone compound that inhibits yeast (Dnm1) and mammalian (Drp1) division DRPs (dynamin-related GTPases) and effectively induces mitochondrial fusion into net-like structures in a reversible manner. Cell-free studies indicate that mdivi-1 blocks Dnm1 ATPase activity (IC50<10 μM) and self-assembly by an allosteric modulation-based mechanism. Mdivi-1 is shown to effectively suppress STS- as well as C8-Bid-induced MOMP (Mitochondrial Outer Membrane Permeabilization) in HeLa cultures and in cell-free murine liver mitochondria preparations, respectively, as assessed by cytochrome C release. In cells, mdivi-1 retards apoptosis by inhibiting mitochondrial outer membrane permeabilization. In principle, mivi-1 represents a class of therapeutics for stroke, myocardial infarction, and neurodegenerative diseases.
In vivo
Drp1 and GFAP protein expression is significantly increased in the early neurodegenerative events of ischemic mouse retina. Mdivi-1 treatment blocks apoptotic cell death in ischemic retina, and significantly increases RGC survival at 2 weeks after ischemia. In the normal mouse retina, Drp1 is expressed in the ganglion cell layer (GCL) as well as the inner plexiform layer, the inner nuclear layer (INL), and the outer plexiform layer (OPL). In the GCL, Drp1 immunoreactivity is strong in RGCs. While Drp1 protein expression is increased in the GCL of vehicle-treated ischemic retina at 12 hours. Mdivi-1 treatment does not change this increase of Drp1 protein expression but significantly decreased GFAP protein expression.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥97%
| Isomeri SMILES | COC1=C(C=C(C(=C1)N2C(=O)C3=CC=CC=C3NC2=S)Cl)Cl |
|---|---|
| Peso molecolare | 353.23 |
| Reaxy-Rn | 23802926 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23802926&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | Data | Oggetto |
|---|---|---|---|
 I2424394 | Certificate of Analysis | Jul 22, 2026 | M407882 |
| Punto di fusione (°C) | 289℃ |
|---|
| 1. Yan Xiao-dan, Fan Rong-hua, Wang Yu, Duan Xiao-xu, Wei Xuan, Li Lin-sen, Yu Qing. (2025) α-asarone activates mitophagy to relieve diabetic encephalopathy via inhibiting apoptosis and oxidative stress. METABOLIC BRAIN DISEASE, 40 (2): (1-16). [PMID:39954135] [10.1007/s11011-025-01556-3] |
| 2. Hao Ling, Chunli Song. (2025) Oleuropein Modulates Mitophagy and Metabolism in Cardiomyocyte Via the PINK1/Parkin Signaling Pathway. DRUG DEVELOPMENT RESEARCH, 86 (7): (e70171). [PMID:41001689] [10.1002/ddr.70171] |
| 3. Hao Ling, Yu Zhang, Chunli Song. (2025) Chlorogenic acid modulates mitochondrial damage and mitophagy to repair injured myocardial tissue and cells. Frontiers in Pharmacology, [PMID:41104339] [10.3389/fphar.2025.1658090] |
| 4. Hao Ling, Annan Liu, Yu Zhang, Quan Lin, Chunli Song. (2026) Biomimetic Selenium-Encrusted Prussian Blue Nanozyme for Myocardial Infarction by Coordinated Enhancement of Mitophagy and Reactive Oxygen Species Scavenging. ACS Nano, [PMID:41665146] [10.1021/acsnano.5c17071] |
| 5. Yu Jia-Xin, Zhang Wen-Xuan, Li Pu-Yu, Yang Yi-Liang, Huang Han-Chang. (2026) Curcumin Rescues Oxidative Stress-Induced Impairment of PINK1/Parkin Pathway-Mediated Mitophagy in APOE4-Expressing Astrocytes. MOLECULAR NEUROBIOLOGY, 63 (1): (454). [PMID:41706344] [10.1007/s12035-026-05744-9] |
