Meprednisone - ≥99% , Glucocorticoid receptor agonist, CAS No.1247-42-3, Glucocorticoid receptor agonist

CAS: 1247-42-3 Cat. No.: M129199 Formula: C₂₂H₂₈O₅ Peso molecolare: 372.455 Numero EC: 214-996-1

GRADE & PURITY ≥99%

Synonyms

(16beta)-17,21-diidrossi-16-metilpregna-1,4-diene-3,11,20-trione | MEPREDNISONE [MART.] | Pregna-1,4-diene-3,11,20-trione, 17,21-diidrossi-16-metil-, (16.beta.)- | Betapar (Meprednisone) | DTXSID8023260 | Meprednisone [USAN:USP:INN] | SR-01000945264-1 |

Storage

Conservare a 2-8°C

Shipped In

Ghiaccio umido

Panoramica

Il meprednisone è un glucocorticoide e un derivato metilato del prednisone.

Specifications

Sinonimi

(16beta)-17,21-diidrossi-16-metilpregna-1,4-diene-3,11,20-trione | MEPREDNISONE [MART.] | Pregna-1,4-diene-3,11,20-trione, 17,21-diidrossi-16-metil-, (16.beta.)- | Betapar (Meprednisone) | DTXSID8023260 | Meprednisone [USAN:USP:INN] | SR-01000945264-1 |

Specifiche e purezza

≥99%

Meccanismi biochimici e fisiologici

Il meprednisone è un glucocorticoide.

Condizioni di conservazione di stoccaggio

Conservare a 2-8°C

Spedito in

Ghiaccio umido

Tipo di azione

AGONIST

Meccanismo d'azione

Glucocorticoid receptor agonist

Purezza

≥99%

Proprietà del prodotto

• ALogP: 1.9

Nomi e identificatori

• Pubchem Sid: 488195293
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488195293
• Sorrisi canonici: CC1CC2C3CCC4=CC(=O)C=CC4(C3C(=O)CC2(C1(C(=O)CO)O)C)C
• IUPAC Name: (8S,9S,10R,13S,14S,16S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
• InChIKey: PIDANAQULIKBQS-RNUIGHNZSA-N
• INCHI: 1S/C22H28O5/c1-12-8-16-15-5-4-13-9-14(24)6-7-20(13,2)19(15)17(25)10-21(16,3)22(12,27)18(26)11-23/h6-7,9,12,15-16,19,23,27H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19+,20-,21-,22-/m0/s1
• Isomeri SMILES: C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@H]3C(=O)C[C@@]2([C@]1(C(=O)CO)O)C)C
• Peso molecolare: 372.455
• Reaxy-Rn: 3481452
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3481452&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Classe Steroids and steroid derivatives
      • Subclass Hydroxysteroids

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Classe: Steroids and steroid derivatives
• Subclass: Hydroxysteroids
• Intermediate Tree Nodes: Not available
• Direct Parent: 21-hydroxysteroids
• Alternative Parents: Gluco/mineralocorticoids, progestogins and derivatives 20-oxosteroids 3-oxo delta-1,4-steroids 17-hydroxysteroids 11-oxosteroids Delta-1,4-steroids Tertiary alcohols Alpha-hydroxy ketones Cyclic ketones Cyclic alcohols and derivatives Primary alcohols Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic homopolycyclic compounds
• Substituents: 21-hydroxysteroid - Progestogin-skeleton - Pregnane-skeleton - 20-oxosteroid - 3-oxo-delta-1,4-steroid - 3-oxosteroid - 17-hydroxysteroid - Oxosteroid - 11-oxosteroid - Delta-1,4-steroid - Alpha-hydroxy ketone - Tertiary alcohol - Cyclic alcohol - Cyclic ketone - Ketone - Organic oxygen compound - Organooxygen compound - Primary alcohol - Carbonyl group - Hydrocarbon derivative - Alcohol - Organic oxide - Aliphatic homopolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

MES-SA (905 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Obiettivi associati (non umani)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: Soluble in Chloroform and Methanol
• Punto di fusione (°C): 204-206°C
• Peso molecolare: 372.500 g/mol
• XLogP3: 1.900
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 372.194 Da
• Monoisotopic Mass: 372.194 Da
• Topological Polar Surface Area: 91.700 Ų
• Heavy Atom Count: 27
• Formal Charge: 0
• Complexity: 795.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 7
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Riferimenti

1. Jianbo Li, Ertai Ye, Jingwen Huang, Meng Xu, Jieke Zhang, Junrong Zhang, Huijie Cai, Jinjie Zhang.  (2024)  Cysteine-modified PEGylated nanoparticles for targeted delivery of methylprednisolone to pancreatitis.  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,      [PMID:38199584] [10.1016/j.ejpb.2024.114179]