mesoridazine - Moligand™ , Antagonist of 5-HT 1A receptor;Antagonist of 5-HT 2A receptor;Antagonist of 5-HT 2C receptor;Antagonist of D 1 receptor;Antagonist of D 2 receptor;Antagonist of D 3 receptor, CAS No.5588-33-0, Antagonist of 5-HT 1A receptor;Antagonist of 5-HT 2A receptor;Antagonist of 5-HT 2C receptor;Antagonist of D 1 receptor;Antagonist of D 2 receptor;Antagonist of D 3 receptor

CAS: 5588-33-0 Cat. No.: M611801 Formula: C₂₁H₂₆N₂OS₂ Peso molecolare: 386.57

GRADE & PURITY Moligand™, ≥98%

Synonyms

DTXSID3023265 | 10-[2-(1-Methyl-2-piperidyl)ethyl]-2-methylsulfinyl phenothiazine | 10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylsulfinyl)- | AB00513854_12 | GTPL7227 | SR-01000759425 | Thioridazine-2-sulfoxide | AKOS027378787 | DTXCID

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

Mesoridazine (TPS-23) , a metabolite of Thioridazine (HY-B0965A), acts as a phenothiazine antipsychotic agent. Mesoridazine is a potent and rapid open-channel blocker of human ether-a-go-go related gene (hERG) channels and blocks hERG currents with an IC50 of 550 nM (at 0 mV) in human embryonic kidney 293 cells.Mesoridazine can be used for the research of schizophrenia, as well as certain other psychiatric disorders.

Specifications

Sinonimi

DTXSID3023265 | 10-[2-(1-Methyl-2-piperidyl)ethyl]-2-methylsulfinyl phenothiazine | 10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylsulfinyl)- | AB00513854_12 | GTPL7227 | SR-01000759425 | Thioridazine-2-sulfoxide | AKOS027378787 | DTXCID

Specifiche e purezza

Moligand™, ≥98%

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

ANTAGONIST

Meccanismo d'azione

Antagonist of 5-HT 1A receptor;Antagonist of 5-HT 2A receptor;Antagonist of 5-HT 2C receptor;Antagonist of D 1 receptor;Antagonist of D 2 receptor;Antagonist of D 3 receptor

Purezza

≥98%

Nomi e identificatori

• Sorrisi canonici: CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)C
• IUPAC Name: 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfinylphenothiazine
• InChIKey: SLVMESMUVMCQIY-UHFFFAOYSA-N
• INCHI: 1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
• Isomeri SMILES: CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)C
• CAS alternativo: 32672-69-8
• Peso molecolare: 386.57

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Benzothiazines
      • Subclass Phenothiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Benzothiazines
• Subclass: Phenothiazines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenothiazines
• Alternative Parents: Alkyldiarylamines Diarylthioethers Piperidines Benzenoids 1,4-thiazines Trialkylamines Sulfoxides Sulfinyl compounds Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenothiazine - Alkyldiarylamine - Diarylthioether - Aryl thioether - Tertiary aliphatic/aromatic amine - Para-thiazine - Piperidine - Benzenoid - Sulfoxide - Tertiary amine - Tertiary aliphatic amine - Thioether - Sulfinyl compound - Azacycle - Amine - Organic oxide - Organic nitrogen compound - Organopnictogen compound - Organic oxygen compound - Organosulfur compound - Organonitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
• External Descriptors: phenothiazines - tertiary amino compound - sulfoxide

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Meccanismi d'azione

Proprietà chimiche e fisiche

• Peso molecolare: 386.600 g/mol
• XLogP3: 4.500
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 386.149 Da
• Monoisotopic Mass: 386.149 Da
• Topological Polar Surface Area: 68.100 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 502.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 2
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1