Methyclothiazide - Moligand™, 10mM in DMSO , Thiazide-sensitive sodium-chloride cotransporter inhibitor, CAS No.135-07-9, Thiazide-sensitive sodium-chloride cotransporter inhibitor

CAS: 135-07-9 Cat. No.: M408281 Formula: C₉H₁₁Cl₂N₃O₄S₂ Peso molecolare: 360.24

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Methyclothiazide is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease.
In vitro

Methyclothiazide (0.1 mM) reduces Ca²⁺ contractures with maximal inhibition of 90.4% in SHR aortic rings with endothelium. The inhibitory effect of Methyclothiazide (0.1 mM) on Ca²⁺ contracture is significantly but not totally abolished by the NO synthase inhibitor in SHR aortic rings with functional endothelium. Methyclothiazide (0.1 mM) induces endothelium-dependent inhibition of the vasoconstrictor responses to NE and AVP only in aortas from spontaneously hypertensive rats (SHR) rather than normotensive Wistar Kyoto rats (WKY), and the maximal vasoconstrictive effect of NE and AVP is decreased by 59% and 32.3%, respectively. Methyclothiazide (3.5 mM) inhibits renin release in rat kidney slices.

In vivo

Methyclothiazide (0.1 g/L for the first 5 weeks and 0.2 g/L for the second 2 weeks, drinking water) attenuates development of hypertension in salt-sensitive (DS) rats, but does not affect blood pressure in salt-resistant (DR) ones. The methyclothiazide-treated DOCA-salt rats weigh less than controls or the nonsupplemented DOCA-salt rats at weeks 3 and 4. Methyclothiazide added to the drinking water of DOCA-salt rats attenuates the elevation of blood pressure.
Cell Data

cell lines：PC12 cell

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinonimi

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

Methyclothiazide is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Meccanismo d'azione

Thiazide-sensitive sodium-chloride cotransporter inhibitor

Proprietà del prodotto

• ALogP: 1.4

Nomi e identificatori

• Isomeri SMILES: CN1C(NC2=CC(=C(C=C2S1(=O)=O)S(=O)(=O)N)Cl)CCl
• Peso molecolare: 360.24
• Reaxy-Rn: 765361
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=765361&ln=

Riferimenti

1. Xiaofei Ren, Kui Xu, Jianming Xu, Qiao Mei.  (2023)  Melatonin attenuates monocrotaline-induced hepatic sinusoidal obstruction syndrome in rats via activation of Sirtuin-3.  JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY,      [PMID:37350538] [10.1002/jbt.23422]

2. Xian He, Wanshui Yang, Xinsheng Qin.  (2023)  Ultrasound-assisted multilayer Pickering emulsion fabricated by WPI-EGCG covalent conjugates for encapsulating probiotics in colon-targeted release.  ULTRASONICS SONOCHEMISTRY,      [PMID:37224638] [10.1016/j.ultsonch.2023.106450]

3. Xinsheng Qin, Qingli Bo, Panzhu Qin, Sufang Wang, Kaiyong Liu.  (2022)  Fabrication of WPI-EGCG covalent conjugates/gellan gum double network emulsion gels by duo-induction of GDL and CaCl2 for colon-controlled Lactobacillus Plantarum delivery.  FOOD CHEMISTRY,      [PMID:36240556] [10.1016/j.foodchem.2022.134513]

4. Xin-Sheng Qin, Zhi-Gang Luo, Xiao-Lin Li.  (2020)  An enhanced pH-sensitive carrier based on alginate-Ca-EDTA in a set-type W1/O/W2 double emulsion model stabilized with WPI-EGCG covalent conjugates for probiotics colon-targeted release.  FOOD HYDROCOLLOIDS,      [PMID:] [10.1016/j.foodhyd.2020.106460]

5. Guo Jing, Yang Zu-Cheng, Liu Yi.  (2019)  Attenuating Pulmonary Hypertension by Protecting the Integrity of Glycocalyx in Rats Model of Pulmonary Artery Hypertension.  INFLAMMATION,  42  (6): (1951-1956).  [PMID:31267273] [10.1007/s10753-019-01055-5]

6. Meijuan Tu, Siyuan Sun, Kai Wang, Xueying Peng, Ruihan Wang, Liping Li, Su Zeng, Hui Zhou, Huidi Jiang.  (2013)  Organic cation transporter 1 mediates the uptake of monocrotaline and plays an important role in its hepatotoxicity.  TOXICOLOGY,      [PMID:23831208] [10.1016/j.tox.2013.06.009]