10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 8 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
In vitro
MG-132 displays >1000 times more activity than ZLLal in inhibiting the ZLLL-MCA-degrading activity of 20S proteasome with IC50 of 100 nM versus 110 μM. MG-132 also inhibits calpain with IC50 of 1.2 μM. MG-132 induces neurite outgrowth in PC12 cells at an optimal concentration of 20 nM, displaying 500 times more potency than ZLLal. MG-132 (10 μM) potently inhibits TNF-α-induced NF-κB activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells by inhibition of proteasome-mediated IκBα degradation. MG-132 treatment potently induces p53-dependent apoptosis in KIM-2 cells by 26S proteasome inhibition. Unlike BzLLLCOCHO or PS-341, MG-132 treatment results in weak inhibition of the chymotrypsinlike (CT-L) and peptidylglutamyl peptide hydrolysing (PGPH) activities of the 26S proteasome, whereas multiple myeloma cells (U266 and OPM-2) are more sensitive to induction of apoptosis by MG-132 than BzLLLCOCHO. MG-132 (1 μM) sensitizes TRAIL-resistant prostate cancer cells by activating the AP-1 family members c-Fos and c-Jun, which, in turn, repress the antiapoptotic molecule c-FLIP(L). MG-132 significantly enhances the ability of inositol hexakisphosphate (IP6) to reduce cellular metabolic activity in both PC3 and DU145 androgen-independent prostate cancer (AIPCa) cell lines. [6]
In vivo
Administration of MG-132 effectively rescues the expression levels and plasma membrane localization of dystrophin, β-dystroglycan, α-bdystroglycan, and α-sarcoglycan in skeletal muscle fibers from mdx mice, reduces muscle membrane damage, and ameliorates the histopathological signs of muscular dystrophy. MG-132 treatment significantly reduces immobilization-induced skeletal muscle atrophy in mice, by downregulating the muscle-specific ubiquitin ligases atrogin-1/MAFbx and MuRF-1 mRNA.
Cell Data
cell lines：N/TERT-1 keratinocytes
Concentrations：Dissolved in DMSO, final concentrations ~25 μM
Incubation Time：24 and 48 hours
Powder Purity:
| Isomeri SMILES | CC(C)C[C@@H](C=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1 |
|---|---|
| Peso molecolare | 475.62 |
| Reaxy-Rn | 11627647 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11627647&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubilità | Solubility (25°C) In vitro DMSO: 100 mg/mL (122.85 mM); Ethanol: 100 mg/mL (122.85 mM); Water: Insoluble; |
|---|
| 1. Daohui Gong, Xueping Liu, Pengfei Wu, Yue Chen, Yuhang Xu, Zhan Gao, Hang Qian, Guansong Wang, Binfeng He. (2023) Rab26 alleviates sepsis-induced immunosuppression as a master regulator of macrophage ferroptosis and polarization shift. FREE RADICAL BIOLOGY AND MEDICINE, [PMID:38169213] [10.1016/j.freeradbiomed.2023.12.046] |
| 2. Xingkang Diao, GuoHua Qi, Xinli Li, Yu Tian, Jing Li, Yongdong Jin. (2025) Label-Free Exosomal SERS Detection Assisted by Machine Learning for Accurately Discriminating Cell Cycle Stages and Revealing the Molecular Mechanisms during the Mitotic Process. ANALYTICAL CHEMISTRY, [PMID:39999424] [10.1021/acs.analchem.4c06240] |
| 3. Runyu Dong, Yao Fei, Yiren He, Peng Gao, Bo Zhang, Menglin Zhu, Zhixiong Wang, Longfei Wu, Shuai Wu, Xiaoming Wang, Juan Cai, Zhiqiang Chen, Xueliang Zuo. (2025) Lactylation-Driven HECTD2 Limits the Response of Hepatocellular Carcinoma to Lenvatinib. Advanced Science, [PMID:39976163] [10.1002/advs.202412559] |
| 4. Liyun Zheng, Zhongwei Zhao, Li Chen, Wenjing Yang, Giorgio Ercolani, Pan Qin, Bin Lin, Mengzhu Han, Qiaoyou Weng, Yeyu Zhang, Bin Wu, Minjiang Chen, Zouying Yao, Shiji Fang, Jiansong Ji. (2025) Astragalin Induces Immunogenic Cell Death in Liver Cancer by Targeting NQO2 to Promote ROS-Mediated Endoplasmic Reticulum Stress Pathway. FREE RADICAL BIOLOGY AND MEDICINE, [PMID:40749898] [10.1016/j.freeradbiomed.2025.07.047] |
| 5. Leyao Chen, Xinluan Lv, Xiaoyu Chang, Ruiyong Wang. (2025) Synthesis and Evaluation of Thiosemicarbazone Inhibitors for SARS-CoV-2 Mpro by Spectroscopy and Microscale Thermophoresis. ARCHIV DER PHARMAZIE, 358 (9): (e70089). [PMID:40922402] [10.1002/ardp.70089] |
| 6. Chenchen Zhao, Yan Qin, Haixin Huang, Wei Chen, Yanqing Hu, Xinyu Zhang, Yuying Li, Tian Lan, Wenchao Sun. (2025) PABPC4 Inhibits SADS-CoV Replication by Degrading the Nucleocapsid Protein Through Selective Autophagy. Veterinary Sciences, 12 (3): (257). [PMID:40266995] [10.3390/vetsci12030257] |
| 7. Huang Wenji, Wang Yafang, Ji Ning, Xiao Hehe, Chen Kangyong, Guo Jiahong, Feng Jianhua, Mustafa Nageen, Wang Junya, Feng Hao, Zou Jun. (2025) Zebrafish TRIM2a promotes virus replication via ubiquitination of IRF3 and autophagic cargo receptor p62. JOURNAL OF IMMUNOLOGY, [PMID:40359380] [10.1093/jimmun/vkaf064] |
| 8. Chenchen Zhao, Yan Qin, Haixin Huang, Yuying Li, Xinyu Zhang, Lin Zhou, Lulu Xie, Yimin Zhou, Yanqing Hu, Wei Chen, Tian Lan, Wen-Chao Sun. (2025) BST-2 Promotes N Protein Degradation and Inhibits Viral Replication Through the MARCHF8/NDP52 Autophagy Pathway. Microorganisms, 13 (8): (1865). [PMID:40871369] [10.3390/microorganisms13081865] |
