Mito-TEMPO - Moligand™, ≥98% , CAS No.1334850-99-5

CAS: 1334850-99-5 Cat. No.: M414479 Formula: C₂₉H₃₆ClN₂O₂P Peso molecolare: 511

GRADE & PURITY Moligand™, ≥98%

Synonyms

1-​Piperidinyloxy,2,​2,​6,​6-​tetramethyl-​4-​[[2-​(triphenylphosphonio​)​acetyl]​amino]​-​,chloride (1:1) | [2,2,6,6-Tetramethyl-4-[2-(triphenylphosphonio)acetamido]-1-piperidinyl]oxidanyl Chloride

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

Information

Mito-TEMPO Mito-TEMPO (MT), a mitochondria-targeted superoxide dismutase mimetic, protects against the early phase of acetaminophen (APAP) hepatotoxicity by inhibiting peroxynitrite formation. Mito-TEMPO treatment inhibits APAP-induced RIP3 kinase expression.

Targets

RIP3 kinase

In vitro

Mito-TEMPO improves blastocyst development by superoxide reduction in porcine embryos in vitro.

In vivo

Mito-Tempo (MT) treatment inhibits APAP-induced RIP3 kinase expression, and RIP3-deficient mice shows caspase activation and apoptotic morphology in hepatocytes analogous to MT treatment.

Cell Research(from reference)

Cell lines：Porcine embryos 

Concentrations：0.1\u2009μM 

Specifications

Sinonimi

1-​Piperidinyloxy,2,​2,​6,​6-​tetramethyl-​4-​[[2-​(triphenylphosphonio​)​acetyl]​amino]​-​,chloride (1:1) | [2,2,6,6-Tetramethyl-4-[2-(triphenylphosphonio)acetamido]-1-piperidinyl]oxidanyl Chloride

Specifiche e purezza

Moligand™, ≥98%

Meccanismi biochimici e fisiologici

Mito-TEMPO (MT), a mitochondria-targeted superoxide dismutase mimetic, protects against the early phase of acetaminophen (APAP) hepatotoxicity by inhibiting peroxynitrite formation. Mito-TEMPO treatment inhibits APAP-induced RIP3 kinase expression.

Condizioni di conservazione di stoccaggio

Protected from light,Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Purezza

≥98%

Nomi e identificatori

• Pubchem Sid: 504773195
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773195
• Sorrisi canonici: CC1(CC(CC(N1O)(C)C)NC(=O)C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C.[Cl-]
• IUPAC Name: [2-[(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)amino]-2-oxoethyl]-triphenylphosphanium;chloride
• InChIKey: QJEOOHMMSUBNGG-UHFFFAOYSA-N
• INCHI: 1S/C29H35N2O2P.ClH/c1-28(2)20-23(21-29(3,4)31(28)33)30-27(32)22-34(24-14-8-5-9-15-24,25-16-10-6-11-17-25)26-18-12-7-13-19-26;/h5-19,23,33H,20-22H2,1-4H3;1H
• WGK Germania: 3
• Peso molecolare: 511
• Reaxy-Rn: 34662187
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=34662187&ln=

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 100 mg/mL (196.06 mM); Water: 100 mg/mL (196.06 mM); Ethanol: 100 mg/mL (196.06 mM)
• Sensibilità: Light sensitive；Moisture sensitive；air sensitive；heat sensitive

Riferimenti

1. Xi Yan, Yinghao Niu, Yaojie Wang, Sisi Wei, Lina Han, Zhongyu Guo, Lianmei Zhao, Feng Gao.  (2025)  CMSP exerts anti-tumor effects on small cell lung cancer cells by inducing mitochondrial dysfunction and ferroptosis.  Open Medicine,  20  (1):   [PMID:39822985] [10.1515/med-2024-1100]

2. Guo Junchen, Wang Shanjie, Wan Xin, Liu Xiaoxuan, Wang Zeng, Liang Chenchen, Zhang Zhenming, Wang Ye, Yan Miao, Wu Pengyan, Fang Shaohong, Yu Bo.  (2024)  Mitochondria-derived methylmalonic acid aggravates ischemia–reperfusion injury by activating reactive oxygen species-dependent ferroptosis.  Cell Communication and Signaling,  22  (1): (1-20).  [PMID:38238728] [10.1186/s12964-024-01479-z]

3. Nan Wang, Zhengshan Gao, Honghong Zhan, Lin Jing, Fancheng Meng, Min Chen.  (2025)  Salidroside alleviates doxorubicin-induced hepatotoxicity via Sestrin2/AMPK-mediated pyroptotic inhibition.  FOOD AND CHEMICAL TOXICOLOGY,      [PMID:39993461] [10.1016/j.fct.2025.115335]

4. Dong Han, Yun-Biao Chen, Kai Zhao, Hong-Zhou Li, Xing-Yu Chen, Guo-Zheng Zhu, Chen Tu, Jia-Wen Gao, Jing-Shen Zhuang, Zhi-Yong Wu, Zhao-Ming Zhong.  (2024)  Tanshinone IIA alleviates inflammation-induced skeletal muscle atrophy by regulating mitochondrial dysfunction.  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,      [PMID:39547552] [10.1016/j.abb.2024.110215]

5. Li Xingyu, Tang Zhaoxia, Kuang Liangjian, Wu Yongjian, Huang Xi.  (2025)  Platelet membrane-coated nanoparticles inhibit platelet activation and neutrophil extracellular traps formation in acute lung injury.  Journal of Translational Medicine,  23  (1): (1-15).  [PMID:40713829] [10.1186/s12967-025-06649-2]

6. Binxu Yin, Wentong Tang, Yan Hu, Yuwei Li, Hao Cai, Maocheng Zuo, Lujia Xiao, Tong Xu, Jia Li, Jingwei Hu, Ji-Feng Fei, Heng Wang.  (2026)  Divergent redox states define regenerative outcomes between salamanders and Xenopus.  FREE RADICAL BIOLOGY AND MEDICINE,      [PMID:41932458] [10.1016/j.freeradbiomed.2026.04.001]

Domande frequenti

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1334850-99-5, the molecular formula is C29H36ClN2O2P, and the molecular weight is 511 g/mol. InChIKey QJEOOHMMSUBNGG-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.