Mivotilate - 10mM in DMSO , CAS No.130112-42-4

CAS: 130112-42-4 Cat. No.: M655914 Molecular Weight: 330.45 PubChem CID: 148185

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR) , and acts as a hepatoprotective agent.

In Vitro

Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor. Mivotilate (YH439) has a novel activation mode that tolerates mutation of histidine 285 to tyrosine. Mivotilate induces cytochromes P4501A1/2 (CYP1A1/2) through the aryl hydrocarbon (Ah) receptor. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mivotilate (YH439, 150 mg/kg, p.o.) reduces CYP2E1-mediated NDMA demethylase activity in rats, but shows no obvious effect on NADPH-dependent P450 oxidoreductase activity. Mivotilate (75-300 mg/kg) rapidly decreases immunoreactive CYP2E1 protein. Mivotilate (150 mg/kg, p.o.) inhibits the transcription of CYP2E1 in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal administration

Male outbred Sprague-Dawley rats (weighing 100-150 g) are kept on a 12-h light-dark cycle with NIH 31 autoclavable rat die and water ad libitum. After a single oral administration of Mivotilate (75, 150, and 300 mg/kg body wt, diluted in corn oil) , the animals are sacrificed at different times as indicated. Livers from control (corn oil-treated) , starved (2 days) and Mivotilate -treated animals (n = 5 per group) are immediately excised, freeze-clamped, and processed further. Another group of rats (n = 3) is treated with phenobarbital (100 mg/kg/day) by intraperitoneal injection for 2 days and sacrificed 24 h after the last dose . aladdin has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Aryl hydrocarbon receptor

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR) , and acts as a hepatoprotective agent.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ACTIVATOR

Names and Identifiers

• Isomeric SMILES: CC1=CSC(=N1)NC(=O)C(=C2SCS2)C(=O)OC(C)C
• WGK Germany: 3
• PubChem CID: 148185
• Molecular Weight: 330.45