MK-0557 - 10mM in DMSO , CAS No.328232-95-7

CAS: 328232-95-7 Cat. No.: M654757 Formula: C₂₂H₁₉FN₄O₃ Peso molecolare: 406.41 PubChem CID: 11491176

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a K i of 1.6 nM.

In Vitro

Neuropeptide Y (NPY) is a potent orexigenic neuropeptide, and antagonism of NPY Y1 and NPY Y5 receptors (NPYxR) is considered a potentially important anti-obesity drug target. MK-0557 has a K i =1.3 nM at the human NPY5R, with similar affinities at rhesus, mouse, and rat NPY5R. MK-0557 has no significant binding to the human NPY1R, NPY2R, NPY4R, or mouse NPY6R at concentrations of 10 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MK-0557 antagonizes the effects of the NPY5R-selective agonist on body-weight gain and hyperphagia in C57BL/6J mice and significantly suppresses the body-weight gain in diet-induced obese (DIO) mice. When lean mice on regular chow are switched to a medium high-fat diet (4.2 kcal/g) and treated with MK-0557 at 30 mg/kg PO QD, MK-0557 causes a 40% reduction in\nbody-weight gain at day 35. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:NPY Y 5 receptor

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a K i of 1.6 nM.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

ANTAGONIST

Nomi e identificatori

• Isomeri SMILES: C1CC2(CCC1C(=O)NC3=NN(C=C3)C4=CC=CC=C4F)C5=C(C=CN=C5)C(=O)O2
• CAS alternativo: 328232-95-7,935765-76-7
• PubChem CID: 11491176
• Termini MeSH: MK-0557;MK0557;spiro(cyclohexane-1,3'(1'H)-furo(3,4-C)pyridine)-4-carboxamide, N-(1-(2-fluorophenyl)-1h-pyrazol-3-yl)-1'-oxo-, trans-;trans-N-(1-(2-fluorophenyl)-3-pyrazolyl)-3-oxospiro(6-azaisobenzofuran-1(3H),1'-cyclohexane)-4'-carboxamide
• Peso molecolare: 406.41

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 328232-95-7, the molecular formula is C22H19FN4O3, and the molecular weight is 406.41 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.