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· · COA & SDS available for every product · Same-day shipping on in-stock items MK 0677 - 10mM in DMSO , Ghrelin receptor agonist, CAS No.159752-10-0, Ghrelin receptor agonist
GRADE & PURITY 10mM in DMSO
Synonyms
2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide;methanesulfonic acid | 2-Amino-N-{3-(benzyloxy)-1-[1-(methanesulfonyl)-1,2-dihydrospiro[indole-3,4'-piperidin]-1'-yl]-1-oxopro
Shipped In
Dry ice packs + Cold packs
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Why this grade 10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonyms
2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3, 4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide;methanesulfonic acid | 2-Amino-N-{3-(benzyloxy)-1-[1-(methanesulfonyl)-1, 2-dihydrospiro[indole-3, 4'-piperidin]-1'-yl]-1-oxopro
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
High affinity ghrelin receptor agonist (pKi= 8.14). Growth hormone (GH) secretagog; stimulates GH release from rat pituitary cellsin vitro(EC50= 1.3 nM) and enhances GH plasma levelsin vivo. Also attenuatesisoproterenol-induced lipolysis in rat adipocytes
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action
Ghrelin receptor agonist
Names and Identifiers Canonical Smiles CC(C)(C(=O)NC(COCC1=CC=CC=C1)C(=O)N2CCC3(CC2)CN(C4=CC=CC=C34)S(=O)(=O)C)N.CS(=O)(=O)O IUPAC Name 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide;methanesulfonic acid InChIKey DUGMCDWNXXFHDE-VZYDHVRKSA-N INCHI 1S/C27H36N4O5S.CH4O3S/c1-26(2,28)25(33)29-22(18-36-17-20-9-5-4-6-10-20)24(32)30-15-13-27(14-16-30)19-31(37(3,34)35)23-12-8-7-11-21(23)27;1-5(2,3)4/h4-12,22H,13-19,28H2,1-3H3,(H,29,33);1H3,(H,2,3,4)/t22-;/m1./s1 Isomeric SMILES CC(C)(C(=O)N[C@H](COCC1=CC=CC=C1)C(=O)N2CCC3(CC2)CN(C4=CC=CC=C34)S(=O)(=O)C)N.CS(=O)(=O)O PubChem CID 6450830 Molecular Weight 624.77
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organic acids and derivatives Class Carboxylic acids and derivatives Subclass Amino acids, peptides, and analogues Intermediate Tree Nodes Peptides Direct Parent Dipeptides Alternative Parents N-acyl-alpha amino acids and derivatives Alpha amino acid amides N-acylpiperidines Indoles and derivatives Benzylethers Organosulfonamides Organic sulfonamides Tertiary carboxylic acid amides Sulfonyls Organosulfonic acids Alkanesulfonic acids Methanesulfonates Secondary carboxylic acid amides Azacyclic compounds Dialkyl ethers Carbonyl compounds Hydrocarbon derivatives Monoalkylamines Organic oxides Molecular Framework Not available Substituents Alpha-dipeptide - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Alpha-amino acid or derivatives - Benzylether - Indole or derivatives - N-acyl-piperidine - Monocyclic benzene moiety - Benzenoid - Piperidine - Organic sulfonic acid amide - Organosulfonic acid amide - Methanesulfonate - Alkanesulfonic acid - Tertiary carboxylic acid amide - Organic sulfonic acid or derivatives - Sulfonyl - Organosulfonic acid or derivatives - Organosulfonic acid - Amino acid or derivatives - Secondary carboxylic acid amide - Carboxamide group - Dialkyl ether - Ether - Azacycle - Organoheterocyclic compound - Organic oxide - Hydrocarbon derivative - Organonitrogen compound - Carbonyl group - Amine - Primary amine - Organooxygen compound - Organic nitrogen compound - Primary aliphatic amine - Organosulfur compound - Organic oxygen compound - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solvent:water, Max Conc. mg/mL: 31.24, Max Conc. mM: 50; Solvent:DMSO, Max Conc. mg/mL: 62.48, Max Conc. mM: 100 Sensitivity Moisture & heat sensitive Molecular Weight 624.800 g/mol XLogP3 Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 10 Rotatable Bond Count 8 Exact Mass 624.229 Da Monoisotopic Mass 624.229 Da Topological Polar Surface Area 193.000 Ų Heavy Atom Count 42 Formal Charge 0 Complexity 1010.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 1 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 2
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