ML252 - ≥99% , CAS No.1392494-64-2

CAS: 1392494-64-2 Cat. No.: M1438161 Molecular Weight: 344.9 PubChem CID: 53393831

GRADE & PURITY ≥99%

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

ML252 is a selective inhibitor of KCNQ2 (Kv7.2) channel with an IC 50 s of 69 nM, 2.92 μM, 0.12 μM and 0.20 μM for KCNQ2, KCNQ1 (Kv7.1), KCNQ2/Q3 and KCNQ4, respectively. ML252 also inhibits Cytochrome P450 with IC 50 s of 6.1 nM ( CYP1A2 ), 18.9 nM ( CYP2C9 ), 3.9 nM ( CYP3A4 ), 19.9 nM ( CYP2D6 ), respectively. ML252 shows highly brain penetrant.

Specifications

Specifications & Purity

≥99%

Storage

Protected from light, Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CCC(C1=CC=CC=C1)C(=O)NC2=CC=CC=C2N3CCCC3.Cl
• IUPAC Name: (2S)-2-phenyl-N-(2-pyrrolidin-1-ylphenyl)butanamide;hydrochloride
• InChIKey: XBYCQOZNTLUEDX-LMOVPXPDSA-N
• INCHI: 1S/C20H24N2O.ClH/c1-2-17(16-10-4-3-5-11-16)20(23)21-18-12-6-7-13-19(18)22-14-8-9-15-22;/h3-7,10-13,17H,2,8-9,14-15H2,1H3,(H,21,23);1H/t17-;/m0./s1
• Isomeric SMILES: CC[C@@H](C1=CC=CC=C1)C(=O)NC2=CC=CC=C2N3CCCC3.Cl
• WGK Germany: 3
• PubChem CID: 53393831
• Molecular Weight: 344.9