MLi-2 - Moligand™, 10mM in DMSO , Inhibitor of leucine rich repeat kinase 2, CAS No.1627091-47-7, Inhibitor of leucine rich repeat kinase 2

CAS: 1627091-47-7 Cat. No.: M408789 Formula: C₂₁H₂₅N₅O₂ Peso molecolare: 379.46

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

1H-​Indazole, 3-​[6-​[(2R,​6S)​-​2,​6-​dimethyl-​4-​morpholinyl]​-​4-​pyrimidinyl]​-​5-​[(1-​methylcyclopropyl)​oxy]​-​, rel-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

MLi-2 MLi-2 is an orally active and highly selective inhibitor of LRRK2 . MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro with IC50 of 0.76 nM, a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 with IC50 o
In vitro

MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM). MLi-2 has greater than 295-fold selectivity for over 300 kinases in addition to a diverse panel of receptors and ion channels.

In vivo

Acute oral and subchronic dosing in MLi-2 mice resulted in dosedependent central and peripheral target inhibition over a 24-hour period as measured by dephosphorylation of pSer935 LRRK2. Treatment of MitoPark mice with MLi-2 is well tolerated over a 15-week period at brain and plasma exposures >100× the in vivo plasma IC50 for LRRK2 kinase inhibition as measured by pSer935 dephosphorylation. Morphologic changes in the lung, consistent with enlarged type II pneumocytes, are observed in MLi-2-treated MitoPark mice.
Cell Data

cell lines：U87-MG, T98G, and U373-MG

Concentrations：10 serial 3-fold dilutions, top concentration 5 μM

Incubation Time：90 min

Powder Purity:≥98%

Specifications

Sinonimi

1H-​Indazole, 3-​[6-​[(2R,​6S)​-​2,​6-​dimethyl-​4-​morpholinyl]​-​4-​pyrimidinyl]​-​5-​[(1-​methylcyclopropyl)​oxy]​-​, rel-

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

MLi-2 is an orally active and highly selective inhibitor of LRRK2. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro with IC50 of 0.76 nM, a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 with IC50 of 1.4 nM,

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Meccanismo d'azione

Inhibitor of leucine rich repeat kinase 2

Nomi e identificatori

• Isomeri SMILES: C[C@@H]1CN(C[C@@H](O1)C)C2=NC=NC(=C2)C3=NNC4=C3C=C(C=C4)OC5(CC5)C
• Peso molecolare: 379.46
• Reaxy-Rn: 35816280
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=35816280&ln=

Obiettivi associati (umani)

LRRK2 Tchem Leucine-rich repeat serine/threonine-protein kinase 2 (4 Activities)

Discover Target: LRRK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Domande frequenti

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1627091-47-7, the molecular formula is C21H25N5O2, and the molecular weight is 379.46 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.