MMP2-IN-1 , CAS No.2764598-01-6

CAS: 2764598-01-6 Cat. No.: M648784 Formula: C₁₅H₁₃NO₅S Peso molecolare: 319.33

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

MMP2-IN-1 is a moderate potenet MMP2 inhibitor with IC 50 of 6.8 µM. MMP2-IN-1 exhibits remarkable antiproliferative activity in certain cancer cells by arresting the cell cycle and inducing apoptosis

In Vitro

MMP2-IN-1 (compound 4a) (0-10 μM; 74 hours) exhibits IC 50 values of 0.07 μM, 0.11 μM, and 0.18 μM against MDA-MB-231, A549, and HeLa cancer cells, respectively, and over 10 μM in Hep 5G cells. MMP2-IN-1 (10 μM; 24 hours) induces cell cycle arrest in the S phase. MMP2-IN-1 (0.01 μM, 0.1 μM, 1 μM and 10 μM; 24 hours) induces a dose-dependent increment in early-and late-stage apoptosis of MDA-MB-231 cells, and increased the early-stage apoptosis percentage from 4.66% to 10.9% at 10 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay Cell Line: MDA-MB-231, A549, HeLa and Hep 5G cellsConcentration: 0-10 μM Incubation Time: 74 hours Result: Exhibited IC 50 values of 0.07 μM, 0.11 μM, and 0.18 μM against MDA-MB-231, A549, and HeLa cancer cells, respectively, and over 10 μM in Hep 5G cells. Cell Cycle Analysis Cell Line: MDA-MB-231Concentration: 10 μM Incubation Time: 24 hours Result: Induced cell cycle arrest in the S phase. Apoptosis Analysis Cell Line: MDA-MB-231Concentration: 0.01 μM, 0.1 μM, 1 μM and 10 μM Incubation Time: 24 hours Result: Induced a dose-dependent increment in early-and late-stage apoptosis of MDA-MB-231 cells, and increased the early-stage apoptosis percentage from 4.66% to 10.9% at 10 μM.

In Vivo

MMP2-IN-1 (100 mg/kg, 150 mg/kg, 200 mg/kg, 250 mg/kg; IP, single) causes 0%, 30%, 50% and 60% mortality rate at dosing 100 mg/kg, 150 mg/kg, 200 mg/kg and 250 mg/kg respectively . MMP2-IN-1 (10 mg/kg; IP, daily, for 14 days) significantly inhibits tumor growth in metastatic 4T1 murine breast cancer model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Kunming mice (n = 10, half male and half female) Dosage: 100 mg/kg, 150 mg/kg, 200 mg/kg, 250 mg/kg Administration: IP, single Result: No mortality occurred after administration of 100 mg/kg, and the mortality rate was 30%, 50% and 60% at dosing 150 mg/kg, 200 mg/kg, 250 mg/kg respectively. Animal Model: Orthotopic 4T1 tumor-bearing mice Dosage: 10 mg/kg Administration: IP, daily, for 14 days Result: Significantly inhibited tumor growth in metastatic 4T1 murine breast cancer model.

Form:Solid

IC50& Target:MMP2 6.8 μM (IC 50 )

Specifications

Meccanismi biochimici e fisiologici

MMP2-IN-1 is a moderate potenet MMP2 inhibitor with IC 50 of 6.8 µM. MMP2-IN-1 exhibits remarkable antiproliferative activity in certain cancer cells by arresting the cell cycle and inducing apoptosis.

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Nomi e identificatori

• Peso molecolare: 319.33

Domande frequenti

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2764598-01-6, the molecular formula is C15H13NO5S, and the molecular weight is 319.33 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.