Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) is an antagonist ofCXCR4with IC50 of ～1 nM. BL-8040 induces theapoptosisof AML blasts by down-regulatingERK,BCL-2,MCL-1andcyclin-D1via altered miR-15a/16-1 expression.
Targets
ERK ; Bcl-2 ; MCL-1 ; cyclin-D1 ; CXCR4 (Cell-free assay) ; 1 nM
In vitro
Treatment with BL-8040 induces the robust mobilization of AML blasts from the BM. In addition, AML cells exposed to BL-8040 undergoes differentiation. BL-8040 induces the apoptosis of AML cells in vitro. This apoptosis is mediated by the up-regulation of miR-15a/miR-16-1, resulting in down-regulation of the target genes BCL-2, MCL-1 and cyclin-D1. Overexpression of miR-15a/miR-16-1 directly induces leukemic cell death. BL-8040-induced apoptosis is also mediated by the inhibition of survival signals via the AKT/ERK pathways.
In vivo
BL-8040 induces the apoptosis of AML cells in vivo. Treatment with a BCL-2 inhibitor induces apoptosis and acts together with BL-8040 to enhance cell death. BL-8040 also synergizes with FLT3 inhibitors to induce AML cell death. Importantly, this combined treatment prolongs the survival of tumor-bearing mice and reduces minimal residual disease in vivo.
Cell Research(from reference)
Cell lines：The leukemic cell lines (MV4-11, THP-1, U937, HL-60)
Concentrations：0.1 μM, 1 μM, 10 μM, 20 μM
Incubation Time：24 h, 48 h
| Peso molecolare | 2159.52(free base) |
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Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Data | Oggetto |
|---|---|---|---|
 H2213268 | Certificate of Analysis | May 12, 2025 | M414450 |
| H2213269 | Certificate of Analysis | May 12, 2025 | M414450 |
| H2213270 | Certificate of Analysis | May 12, 2025 | M414450 |
| H2213271 | Certificate of Analysis | May 12, 2025 | M414450 |
| Solubilità | Solubility (25°C) In vitro Water: 100 mg/mL (46.3 mM); |
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