MPP+ iodide - 10mM in DMSO , CAS No.36913-39-0

CAS: 36913-39-0 Cat. No.: M423656 Formula: C₁₂H₁₂IN Peso molecolare: 297.13 Numero EC: 627-416-0 PubChem CID: 10924457

QUALITÀ & PUREZZA 10mM in DMSO

Synonyms

HY-W008719 | MPP+ iodide | FT-0672164 | Q27284640 | SCHEMBL2203363 | MPP iodide | UNII-N708D004VE | N-Methyl-4-phenylpyridiniumIodide | D95477 | MPP+ (iodide) | Cyperquat iodide | N-Methyl-4-phenylpyridinium iodide | Pyridinium, 1-methyl-4-phenyl-, iodide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Product Describtion:
1-Methyl-4-phenylpyridinium (MPP+) induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.

Product Application： MPP+ iodide has been used: to induce oxidative stress in zebrafish embryos for the inhibition of glutamate uptake in mitochondria of astrocytes in testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells

Specifiche

Sinonimi

HY-W008719 | MPP+ iodide | FT-0672164 | Q27284640 | SCHEMBL2203363 | MPP iodide | UNII-N708D004VE | N-Methyl-4-phenylpyridiniumIodide | D95477 | MPP+ (iodide) | Cyperquat iodide | N-Methyl-4-phenylpyridinium iodide | Pyridinium, 1-methyl-4-phenyl-, iodide

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP.Dopaminergic selective neurotoxin. Active MPTP metabolite. Interferes with oxidative phosphorylation and induces mitochondrial dysfunction. Deplete cellular ATP. Shows Parkinson effects i

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

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Tipo di azione

INHIBITOR

Nomi e identificatori

Pubchem Sid

528766127

Sorrisi canonici

C[N+]1=CC=C(C=C1)C2=CC=CC=C2.[I-]

IUPAC Name

1-methyl-4-phenylpyridin-1-ium;iodide

InChIKey

RFDFRDXIIKROAI-UHFFFAOYSA-M

INCHI

1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1

Isomeri SMILES

C[N+]1=CC=C(C=C1)C2=CC=CC=C2.[I-]

WGK Germania

3

RTECS

UU6580000

PubChem CID

10924457

Numero UN

2811

Gruppo di imballaggio

II

Peso molecolare

297.13

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Pyridines and derivatives
      • Subclass Phenylpyridines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Pyridines and derivatives
• Subclass: Phenylpyridines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpyridines
• Alternative Parents: N-methylpyridinium compounds Pyridinium derivatives Benzene and substituted derivatives Heteroaromatic compounds Azacyclic compounds Organonitrogen compounds Organic iodide salts Hydrocarbon derivatives Organic cations
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: 4-phenylpyridine - N-methylpyridinium - Benzenoid - Pyridinium - Monocyclic benzene moiety - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organic iodide salt - Organic salt - Organonitrogen compound - Organic cation - Aromatic heteromonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as phenylpyridines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

SLC18A2 Tclin Synaptic vesicular amine transporter (118 Activities)

Discover Target: SLC18A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SH-SY5Y (11521 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione

Proprietà chimiche e fisiche

• Sensibilità: light ＆ Moisture sensitive
• Peso molecolare: 297.130 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 297.001 Da
• Monoisotopic Mass: 297.001 Da
• Topological Polar Surface Area: 3.900 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 141.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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