MR-L2 - ≥99% , CAS No.2374703-19-0

CAS: 2374703-19-0 Cat. No.: M651795 Formula: C₁₉H₁₆Cl₃FN₄O Peso molecolare: 441.71 PubChem CID: 138911347

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4) , activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC 50 of 1.2 µM

In Vitro

MR-L2 (0.3-10 μM; 1 h) significantly suppresses cAMP elevation and cysts formation in MDCK cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Madin-Darby Canine Kidney (MDCK) cell line Concentration: 0.3, 1, 3 and 10 μM Incubation Time: 1 hour Result: Suppressed cAMP elevation but not enhanced cAMP excretion in MDCK cells. Suppressed cysts formation in MDCK cells with an EC 50 value of 1.2 µM. Suppressed the number of cysts formation in 3D culture for both unstimulated and Vasotocin-treated culture condition while showed no effect on cell viability.

Form:Solid

IC50& Target:PDE4

Specifications

Specifiche e purezza

≥99%

Meccanismi biochimici e fisiologici

MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4) , activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

ACTIVATOR

Purezza

≥99%

Nomi e identificatori

• Sorrisi canonici: CCC1=NC(=NN1CC(=O)NCC2=CC(=CC(=C2)Cl)Cl)C3=CC(=C(C=C3)Cl)F
• IUPAC Name: 2-[3-(4-chloro-3-fluorophenyl)-5-ethyl-1,2,4-triazol-1-yl]-N-[(3,5-dichlorophenyl)methyl]acetamide
• InChIKey: JXACCOKEEPXHCF-UHFFFAOYSA-N
• INCHI: 1S/C19H16Cl3FN4O/c1-2-17-25-19(12-3-4-15(22)16(23)7-12)26-27(17)10-18(28)24-9-11-5-13(20)8-14(21)6-11/h3-8H,2,9-10H2,1H3,(H,24,28)
• PubChem CID: 138911347
• Peso molecolare: 441.71

Proprietà chimiche e fisiche

• Solubilità: DMSO : 83.33 mg/mL (188.65 mM; Need ultrasonic)

Domande frequenti

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2374703-19-0, the molecular formula is C19H16Cl3FN4O, and the molecular weight is 441.71 g/mol. InChIKey JXACCOKEEPXHCF-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.