MRIA9 - ≥98% , CAS No.2750707-05-0

CAS: 2750707-05-0 Cat. No.: M651167 Formula: C₂₄H₂₂ClFN₆O₃ Peso molecolare: 496.92

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

MRIA9 is an ATP-competitive, pan Salt-Inducible kinase (SIK) and PAK2/3 inhibitor, with IC 50 values of 516 nM, 180 nM and 127 nM for SIK1 , SIK2 and SIK3 , respectively

In Vitro

MRIA9 (5 μM) MRIA9 sensitizes SKOV3 cells to paclitaxel treatment through inducing pronounced apoptosis. MRIA9 (5 μM) with paclitaxel (2 nM) significantly enhances cell death in HeLa cells. MRIA9 strongly impedes centrosome function, causes mitotic spindle mispositioning in ovarian cancer cell lines, prevents the centrosome disjunction during the late G2 phase, and sensitized ovarian cancer cells and patient derived 3D-spheroids to paclitaxel treatment. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: SKOV3 cells. Concentration: 0.5-5 μM (1 nM paclitaxel). Incubation Time: 9 days. Result: Inhibited cell growth.

In Vivo

MRIA9 shows high oral bioavailability (F = 75-80%) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:SIK1 SIK2 SIK3

Specifications

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

MRIA9 is an ATP-competitive, pan Salt-Inducible kinase (SIK) and PAK2/3 inhibitor, with IC 50 values of 516 nM, 180 nM and 127 nM for SIK1 , SIK2 and SIK3 , respectively.

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Purezza

≥98%

Nomi e identificatori

• Peso molecolare: 496.92

Proprietà chimiche e fisiche

• Solubilità: DMSO : 66.67 mg/mL (134.17 mM; Need ultrasonic)

Domande frequenti

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2750707-05-0, the molecular formula is C24H22ClFN6O3, and the molecular weight is 496.92 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.