MRZ 2-514 - Moligand™,≥98% , CAS No.202808-11-5

CAS: 202808-11-5 Cat. No.: M651325 Formula: C₁₁H₆BrN₃O₃ Peso molecolare: 308.09 PubChem CID: 9801704

GRADE & PURITY Moligand™, ≥98%

Synonyms

8-Bromo-1,4-dioxo-1,2,3,4-tetrahydropyridazino[4,5-b]quinoline 5-oxide

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with K i of 33 μM.

In Vitro

MRZ 2-514 has IC 50 values against peak AMPA-induced currents of 72.7 μM.

In Vivo

MRZ 2/514 has anticonvulsive action in the MES model in mice, and the effect is prolonged by probenecid .

Form:Solid

IC50& Target:Ki: 33 μM (glycineB)

Specifications

Sinonimi

8-Bromo-1,4-dioxo-1,2,3,4-tetrahydropyridazino[4,5-b]quinoline 5-oxide

Specifiche e purezza

Moligand™,≥98%

Meccanismi biochimici e fisiologici

MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with K i of 33 μM.

Condizioni di conservazione di stoccaggio

Protected from light,Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

ANTAGONIST

Purezza

≥98%

Nomi e identificatori

• Sorrisi canonici: C1=CC2=C(C=C1Br)C=C3C(=C(N=NC3=O)O)N2O
• IUPAC Name: 8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one
• InChIKey: AXFGZZXFEDISAJ-UHFFFAOYSA-N
• INCHI: 1S/C11H6BrN3O3/c12-6-1-2-8-5(3-6)4-7-9(15(8)18)11(17)14-13-10(7)16/h1-4,17-18H
• Isomeri SMILES: C1=CC2=C(C=C1Br)C=C3C(=C(N=NC3=O)O)N2O
• PubChem CID: 9801704
• Peso molecolare: 308.09

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Quinolines and derivatives
      • Subclass Haloquinolines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Quinolines and derivatives
• Subclass: Haloquinolines
• Intermediate Tree Nodes: Not available
• Direct Parent: Haloquinolines
• Alternative Parents: Pyridazinones Pyridines and derivatives Benzenoids Aryl bromides Vinylogous amides Heteroaromatic compounds Azacyclic compounds Organooxygen compounds Organonitrogen compounds Organobromides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Haloquinoline - Pyridazinone - Aryl bromide - Aryl halide - Pyridazine - Pyridine - Benzenoid - Heteroaromatic compound - Vinylogous amide - Azacycle - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organobromide - Organohalogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as haloquinolines. These are compounds containing a quinoline moiety, which is substituted at one or more ring positions by n halogen atom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Proprietà chimiche e fisiche

• Sensibilità: light sensitive；
• Peso molecolare: 308.090 g/mol
• XLogP3: 2.700
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 306.959 Da
• Monoisotopic Mass: 306.959 Da
• Topological Polar Surface Area: 85.500 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 500.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Domande frequenti

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 202808-11-5, the molecular formula is C11H6BrN3O3, and the molecular weight is 308.09 g/mol. InChIKey AXFGZZXFEDISAJ-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.