MT1 is a bivalent chemical probe of BET bromodomains , with an IC 50 of 0.789 nM for BRD4(1).
In Vitro
MT1 (100 nM, 24 h) significantly induces apoptosis via caspase-3 and PARP in MV4;11 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MV4;11 cells. Concentration: 100 nM. Incubation Time: 24 h. Result: Significant apoptosis was observed by caspase-3 and PARP cleavage after treatment.
In Vivo
MT1 (44.2 and 22.1 µmol/kg, ip daily, for 14 days) significantly delayed leukemia progression in mice (Mus musculus) compared to JQ1 . MT1 exhibits terminal t 1/2 of 2.70 h in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Leukemia xenograft models . Dosage: 44.2 and 22.1 µmol/kg. Administration: Intraperitoneally for 14 subsequent days. Result: Significantly reduced leukemic burden over the course of the study compared to either vehicle or JQ1.
Specifiche
Specifiche e purezza
10mM in DMSO
Meccanismi biochimici e fisiologici
MT1 is a bivalent chemical probe of BET bromodomains , with an IC 50 of 0.789 nM for BRD4(1).
Condizioni di conservazione di stoccaggio
Store at -80°C
Spedito in
Dry ice packs + Cold packs
Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.
Tipo di azione
INHIBITOR
Nomi e identificatori
PubChem CID
122172644
Peso molecolare
1134.20
Dati avanzati
Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
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Recensioni
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Domande frequenti
How should this product be stored?
Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 2060573-82-0, the molecular formula is C54H66Cl2N10O9S2, and the molecular weight is 1134.20 g/mol.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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