MV1 - 10mM in DMSO , CAS No.1001600-54-9

CAS: 1001600-54-9 Cat. No.: M655714 Formula: C₃₃H₄₄N₄O₅ Peso molecolare: 576.73 PubChem CID: 23657865

QUALITÀ & PUREZZA 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

MV1 is an antagonist of IAP (inhibitor of apoptosis protein), leads to protein knockdown of HaloTag-fused proteins when combined with HaloTag ligand.

In Vitro

MV1 (0.08-20 μM; 24 h) inhibits the growth of EVSAT cells. MV1 (5 μM; 0-60 min) treatment causes rapid loss of c-IAP1 and c-IAP2 in MDA-MB-231 cells. MV1 (5 μM; 1 h) treatment inducing degradation of c-IAP1 and c-IAP2 is dependent on proteasomal machinery but not on caspase activation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: EVSAT cells Concentration: 0.08-20 μM Incubation Time: 24 hours Result: Showed IC 50 value of 5 μM for EVSAT cells. Western Blot AnalysisCell Line: MDA-MB-231 cells Concentration: 5 μM Incubation Time: 0-60 min Result: Showed the decreasement of c-IAP1 and 2 protein levels by as early as two minutes following exposure.

Specifiche

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

MV1 is an antagonist of IAP (inhibitor of apoptosis protein), leads to protein knockdown of HaloTag-fused proteins when combined with HaloTag ligand.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

Isomeri SMILES

C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)OC)NC

PubChem CID

23657865

Peso molecolare

576.73