Mycophenolic acid - Moligand™, 10mM in DMSO , Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor, CAS No.24280-93-1, Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor

CAS: 24280-93-1 Cat. No.: M408934 Formula: C₁₇H₂₀O₆ Peso molecolare: 320.34 Beilstein Registry Number: 1295848 Numero EC: 246-119-3

QUALITÀ & PUREZZA Moligand™, 10mM in DMSO

Synonyms

Mycophenolate, RS-61443 | (4E)​-6-​(1,​3-​dihydro-​4-​hydroxy-​6-​methoxy-​7-​methyl-​3-​oxo-​5-​isobenzofuranyl)​-​4-​methyl-4-​hexenoic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Mycophenolic acid Mycophenolic acid (Mycophenolate, RS-61443) is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.
In vitro

Mycophenolic acid inhibits inosine-5\'-monophosphate dehydrogenase (IMPDH) by acting as a replacement for the nicotinamide portion of the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule. Mycophenolic acid (MPA), an inhibitor of inosine monophosphate dehydrogenase, in nanomolar concentrations blocks proliferative responses of cultured human, mouse and rat T lymphocytes and B lymphocytes to mitogens or in mixed lymphocyte reactions. Mycophenolic acid (MPA) suppresses mixed lymphocyte reactions when added 3 days after their initiation. Mycophenolic acid also inhibits antibody formation by polyclonally activated human B lymphocytes. Mycophenolic acid is an immunosuppressive agent reversibly inhibiting proliferation of T and B lymphocytes and antibody formation, with a profile of activity different from that of other immunosuppressive drugs. Mycophenolic acid inhibits the formation of antibodies to sheep erythrocytes. Mycophenolic acid also suppresses, in a dose-related manner, the generation of cytotoxic T-lymphocytes against allogeneic cells in mice and prevents the elimination of allogeneic cells. Mycophenolic acid induces apoptosis and cell death in a large proportion of activated CD4+ T cells.

In vivo

Mycophenolic acid has lymphocyte-selective anti-proliferative effects in mice and can inhibit both cell-mediated and humoral immune responses without major side effects.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifiche

Sinonimi

Mycophenolate, RS-61443 | (4E)​-6-​(1,​3-​dihydro-​4-​hydroxy-​6-​methoxy-​7-​methyl-​3-​oxo-​5-​isobenzofuranyl)​-​4-​methyl-4-​hexenoic acid

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

Mycophenolic acid (Mycophenolate, RS-61443) is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Meccanismo d'azione

Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor

Proprietà del prodotto

ALogP

3.2

Nomi e identificatori

Isomeri SMILES

CC1=C2COC(=O)C2=C(C(=C1OC)C/C=C(\C)/CCC(=O)O)O

WGK Germania

3

RTECS

MP8050000

Peso molecolare

320.34

Beilstein

1295848

Reaxy-Rn

8644904

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8644904&ln=

Obiettivi associati (umani)

IMPDH2 Tclin Inosine-5'-monophosphate dehydrogenase 2 (24 Activities)

Discover Target: IMPDH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IMPDH1 Tclin Inosine-5'-monophosphate dehydrogenase 1 (13 Activities)

Discover Target: IMPDH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Punto di fusione (°C): 141-145℃