MYF-01-37 - 10mM in DMSO , CAS No.2416417-65-5

CAS: 2416417-65-5 Cat. No.: M492060 Formula: C₁₅H₁₇F₃N₂O Peso molecolare: 298.3

GRADE & PURITY 10mM in DMSO

Synonyms

1-(3-(3-(trifluoromethyl)phenylamino)-3-methylpyrrolidin-1-yl)prop-2-en-1-one

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

MYF-01-37 MYF-01-37 is a novel covalent inhibitor of TEAD targeting Cys380 when incubated with the TEAD2 protein.

Targets

TEAD

In vitro

MYF-01-37 is developed as a covalent binder to TEAD, targeting Cys380 when incubated with the TEAD2 protein (C359 in TEAD1). Pretreating cells with MYF-01-37 leads to loss of direct TEAD pull-down by biotin-MYF-01-037 from whole-cell lysate, confirming MYF-01-037 binding to TEAD in cells.

Cell Research(from reference)

Cell lines：PC9 cells 

Concentrations：10 μM, 1 μM 

Incubation Time：6 h 

Specifications

Sinonimi

1-(3-(3-(trifluoromethyl)phenylamino)-3-methylpyrrolidin-1-yl)prop-2-en-1-one

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

MYF-01-37 is a novel covalent inhibitor of TEAD targeting Cys380 when incubated with the TEAD2 protein.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Nomi e identificatori

• Sorrisi canonici: CC1(CCN(C1)C(=O)C=C)NC2=CC=CC(=C2)C(F)(F)F
• IUPAC Name: 1-[3-methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one
• InChIKey: MTBDEVWWJBIUOK-UHFFFAOYSA-N
• INCHI: 1S/C15H17F3N2O/c1-3-13(21)20-8-7-14(2,10-20)19-12-6-4-5-11(9-12)15(16,17)18/h3-6,9,19H,1,7-8,10H2,2H3
• Peso molecolare: 298.3
• Reaxy-Rn: 36048179
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=36048179&ln=

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 60 mg/mL (201.13 mM); Ethanol: 60 mg/mL (201.13 mM); Water: Insoluble
• Peso molecolare: 298.300 g/mol
• XLogP3: 3.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 298.129 Da
• Monoisotopic Mass: 298.129 Da
• Topological Polar Surface Area: 32.299 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 410.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2416417-65-5, the molecular formula is C15H17F3N2O, and the molecular weight is 298.3 g/mol. InChIKey MTBDEVWWJBIUOK-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.