Namitecan - 10mM in DMSO , CAS No.372105-27-6

CAS: 372105-27-6 Cat. No.: N655466 Formula: C₂₃H₂₂N₄O₅ Peso molecolare: 434.44 PubChem CID: 10950142

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Namitecan is a potent topoisomerase I inhibitor, with antitumor property.

In Vitro

Namitecan and cetuximab cooperate in inhibiting EGFR expression. Namitecan induces a dose-dependent decrease in EGFR expression in the different cell lines. ST1968 induces a comparable level of apoptosis in A431 and A431/TPT cells with IC 50 of 0.21 and 0.29 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Namitecan (10 mg/kg) in combination with cetuximab (1 mg/mouse) induces synergistic antitumor effects in SCC models as a function of EGFR gene copy number . ST1968 (25 mg/kg) causes acceptable body weight loss and no toxic deaths. ST1968 produces a 100% complete response rate in the mice bearing the A431 tumor, and retains a relevant activity in the topotecan-resistant tumor. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Topoisomerase I

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Namitecan is a potent topoisomerase I inhibitor, with antitumor property.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Nomi e identificatori

• Isomeri SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)/C=N/OCCN)O
• CAS alternativo: 372105-27-6
• PubChem CID: 10950142
• Termini MeSH: namitecan;ST 1968;ST-1968;ST1968
• Peso molecolare: 434.44

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 372105-27-6, the molecular formula is C23H22N4O5, and the molecular weight is 434.44 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.