Native Human C-Reactive Protein, ≥95% (SDS-PAGE), CAS No.9007-41-4

CAS: 9007-41-4 Cat. No.: np008458 Molecular Weight: 118000

GRADE & PURITY Bioactive, ActiBioPure™, Native, High Performance, ≥95%(SDS-PAGE), See COA; from Human Pleural Effusion

Accession #

P02741

Bioactivity

Measured by its binding ability in a functional ELISA. When Native Human C-Reactive Protein (np008458) is immobilized at 1.0 µg/mL can bind Recombinant CRP Antibody (Ab007977) with the EC50 of 3.88 ng/mL.

Overview

  CRP is an acute-phase reactive protein synthesized by the liver, which can react with the C-polysaccharide of Streptococcus pneumoniae. Its main biological function is to activate the complement system and mononuclear phagocyte system by binding to ligands (phosphorylcholine on apoptotic or necrotic cells, or invading bacteria, fungi, parasites, etc.), thereby clearing pathogens or pathological cells carrying such ligands. When the body suffers from infection, tissue damage or inflammatory diseases, the level of CRP increases rapidly, even by thousands of times; after the disease is cured, its content drops sharply. Therefore, CRP detection can provide valuable information for the diagnosis, treatment and monitoring of inflammatory processes and related diseases.

Specifications

Product Name

Native Human C-Reactive Protein, ≥95% (SDS-PAGE), CAS No.9007-41-4

Synonyms

C-Reactive Protein | C-reactive protein, pentraxin-related | CRP | MGC88244 | pentraxin 1 | PTX1MGC149895

Grade

ActiBioPure™, Bioactive, High Performance, Native

Specifications & Purity

Bioactive, ActiBioPure™, Native, High Performance, ≥95%(SDS-PAGE), See COA; from Human Pleural Effusion

Biochemical and Physiological Mechanisms

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may sc

Purity

≥95% (SDS-PAGE)

Bioactivity

Measured by its binding ability in a functional ELISA. When Native Human C-Reactive Protein (np008458) is immobilized at 1.0 µg/mL can bind Recombinant CRP Antibody (Ab007977) with the EC50 of 3.88 ng/mL.

Accession #

P02741

Predicted molecular weight

11.8 kDa

SDS-PAGE

23.8 kDa, under reducing conditions; 22.4 kDa, under non-reducing conditions.

CAS

9007-41-4

Molecule Type

Protein

Storage and Shipping

Shape

Liquid

Concentration

See COA; from Human Pleural Effusion

Storage

Store at -20°C,Avoid repeated freezing and thawing

Shipped In

Ice chest + Ice pads

Stability And Storage

Store at 2-8 °C short term，Store at-80°C long term(24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

ELISA: Native Human C-Reactive Protein (np008458)

Native Human C-Reactive Protein (np008458) - ELISA
Measured by its binding ability in a functional ELISA. When Native Human C-Reactive Protein (np008458) is immobilized at 1.0 µg/mL can bind Recombinant CRP Antibody (Ab007977) with the EC₅₀ of 3.88 ng/mL.

SDS-PAGE: Native Human C-Reactive Protein (np008458)

Native Human C-Reactive Protein (np008458) - SDS-PAGE
3 μg/lane of Native Human C-Reactive Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 23.8 kDa under reducing conditions and 22.4 kDa under non-reducing conditions.

References

1. Zhenjie Zhang, Wei Wei, Anne Ailina Li, Chenhao Wang, Chengchen Tang, Qing Wang, Lianqun Zhou, Hui Kong.  (2025)  High accuracy sensor for two-parameter detection of adrenaline and pH in sweat.  BIOSENSORS & BIOELECTRONICS,      [PMID:40532433] [10.1016/j.bios.2025.117675]

2. Jia Menggai, Li Yingqi, Qin Ziyao, Li Longwei, Peng Ling, Yang Molin, Hu Beibei, Li Zhiwei, Sun Shiguo.  (2026)  The preparation of two molecularly imprinted electrochemical sensors based on gold nanoparticles and glutaraldehyde and their application in protein detection.  MICROCHIMICA ACTA,  193  (2): (119).  [PMID:41619074] [10.1007/s00604-026-07887-x]