Navocaftor - ≥99% , Cystic fibrosis transmembrane conductance regulator positive modulator, CAS No.2159103-66-7, Cystic fibrosis transmembrane conductance regulator positive modulator

CAS: 2159103-66-7 Cat. No.: N651324 Formula: C₁₅H₁₁F₃N₄O₅S Peso molecolare: 416.33 PubChem CID: 132189640

GRADE & PURITY ≥99%

Synonyms

Navocaftor | CHEMBL4802150 | Navocaftor [USAN:INN] | [5-[3-amino-5-[4-(trifluoromethoxy)phenyl]sulfonylpyridin-2-yl]-1,3,4-oxadiazol-2-yl]methanol | ABBV-3067 | MS-27234 | 1,3,4-Oxadiazole-2-methanol, 5-(3-amino-5-((4-(trifluoromethoxy)phenyl)sulfonyl)-2-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

Navocaftor (GLPG 3067), as a cystic fibrosis transmembrane regulator ( CFTR ), is a protein modulator (US 20200377491 Al, example 1)

In Vitro

Navocaftor, as a cystic fibrosis transmembrane regulator ( CFTR ), is a protein modulator. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:CFTR

Specifications

Sinonimi

Navocaftor | CHEMBL4802150 | Navocaftor [USAN:INN] | [5-[3-amino-5-[4-(trifluoromethoxy)phenyl]sulfonylpyridin-2-yl]-1,3,4-oxadiazol-2-yl]methanol | ABBV-3067 | MS-27234 | 1,3,4-Oxadiazole-2-methanol, 5-(3-amino-5-((4-(trifluoromethoxy)phenyl)sulfonyl)-2-

Specifiche e purezza

≥99%

Meccanismi biochimici e fisiologici

Navocaftor (GLPG 3067), as a cystic fibrosis transmembrane regulator ( CFTR ), is a protein modulator (US 20200377491 Al, example 1).

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

POSITIVE MODULATOR

Meccanismo d'azione

Cystic fibrosis transmembrane conductance regulator positive modulator

Purezza

≥99%

Proprietà del prodotto

• ALogP: 0.8

Nomi e identificatori

• Sorrisi canonici: C1=CC(=CC=C1OC(F)(F)F)S(=O)(=O)C2=CC(=C(N=C2)C3=NN=C(O3)CO)N
• IUPAC Name: [5-[3-amino-5-[4-(trifluoromethoxy)phenyl]sulfonylpyridin-2-yl]-1,3,4-oxadiazol-2-yl]methanol
• InChIKey: WOXOLLSAICIZNO-UHFFFAOYSA-N
• INCHI: 1S/C15H11F3N4O5S/c16-15(17,18)27-8-1-3-9(4-2-8)28(24,25)10-5-11(19)13(20-6-10)14-22-21-12(7-23)26-14/h1-6,23H,7,19H2
• Isomeri SMILES: C1=CC(=CC=C1OC(F)(F)F)S(=O)(=O)C2=CC(=C(N=C2)C3=NN=C(O3)CO)N
• PubChem CID: 132189640
• Peso molecolare: 416.33

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Benzenesulfonyl compounds

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Benzenesulfonyl compounds
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzenesulfonyl compounds
• Alternative Parents: Phenoxy compounds Phenol ethers Aminopyridines and derivatives Sulfones Heteroaromatic compounds 1,3,4-oxadiazoles Trihalomethanes Oxacyclic compounds Azacyclic compounds Primary amines Primary alcohols Organopnictogen compounds Organofluorides Organic oxides Hydrocarbon derivatives Aromatic alcohols Alkyl fluorides
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Benzenesulfonyl group - Phenoxy compound - Phenol ether - Aminopyridine - Pyridine - Heteroaromatic compound - Sulfonyl - Sulfone - Oxadiazole - Azole - 1,3,4-oxadiazole - Trihalomethane - Oxacycle - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Halomethane - Hydrocarbon derivative - Aromatic alcohol - Primary amine - Primary alcohol - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Amine - Alkyl halide - Alkyl fluoride - Alcohol - Aromatic heteromonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as benzenesulfonyl compounds. These are aromatic compounds containing a benzenesulfonyl group, which consists of a monocyclic benzene moiety that carries a sulfonyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Proprietà chimiche e fisiche

• Solubilità: DMSO : <1 mg/mL (ultrasonic) (insoluble or slightly soluble)

Domande frequenti

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2159103-66-7, the molecular formula is C15H11F3N4O5S, and the molecular weight is 416.33 g/mol. InChIKey WOXOLLSAICIZNO-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.