≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 ( ALDH1A1 ) inhibitors with an IC 50 of 7 nM.
In Vitro
NCT-506 inhibits ALDH1A1, hALDH1A3, hALDH2 with IC 50 s of 0.007±0.001, 16.4±3.99, and 21.5 μM, respectively. NCT-506 (100, 10, 1, 0.1 μM, 6 days) decreases significantly cell viability with an EC 50 of 45.6 μM in OV-90 cells. NCT-506 inhibits MIA PaCa-2, OV-90, and HT-29 cells with IC 50 s of 0.077±0.040, 0.161±0.038, and 0.048±0.022 μM in aldefluor cell-based assays, respectively. NCT-506 is treated in combined with Paclitaxel, IC 50 s of 1202, 924, 870, 411, 102, and 31.8 nM with concentrations of NCT-506 at 0 (DMSO), 1, 3, 10, 20, 30 μM in SKOV-3-TR cells, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: OV-90 and SKOV-3-TR cells Concentration: 100, 10, 1, 0.1 μM Incubation Time: 6 days for OV-90 cells; 4 days for SKOV-3-TR cells Result: Decreased significantly cell viability with an EC 50 of 45.6 μM in OV-90 cells. Decreased cell viability in combined treatments (Paclitaxel concentration of 100 nM) with an EC 50 of 11.2 μM in SKOV-3-TR cells.
Form:Solid
| Canonical Smiles | CS(=O)(=O)N1CCN(CC1)C(=O)C2=CN=C3C=CC(=CC3=C2C4=CC=C(C=C4)C5(CC5)C#N)F |
|---|---|
| IUPAC Name | 1-[4-[6-fluoro-3-(4-methylsulfonylpiperazine-1-carbonyl)quinolin-4-yl]phenyl]cyclopropane-1-carbonitrile |
| InChIKey | WIXZFNIBMHEUJH-UHFFFAOYSA-N |
| INCHI | 1S/C25H23FN4O3S/c1-34(32,33)30-12-10-29(11-13-30)24(31)21-15-28-22-7-6-19(26)14-20(22)23(21)17-2-4-18(5-3-17)25(16-27)8-9-25/h2-7,14-15H,8-13H2,1H3 |
| Isomeric SMILES | CS(=O)(=O)N1CCN(CC1)C(=O)C2=CN=C3C=CC(=CC3=C2C4=CC=C(C=C4)C5(CC5)C#N)F |
| PubChem CID | 137628670 |
| Molecular Weight | 478.54 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Quinolines and derivatives |
| Subclass | Phenylquinolines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Phenylquinolines |
| Alternative Parents | Quinoline-3-carboxamides Phenylpyridines Haloquinolines Pyridinecarboxylic acids and derivatives Piperazines Organosulfonamides Organic sulfonamides Benzene and substituted derivatives Aryl fluorides Tertiary carboxylic acid amides Sulfonyls Heteroaromatic compounds Nitriles Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organofluorides Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Phenylquinoline - Quinoline-3-carboxamide - 4-phenylpyridine - Haloquinoline - Pyridine carboxylic acid or derivatives - Benzenoid - Organosulfonic acid amide - Organic sulfonic acid amide - Pyridine - Piperazine - 1,4-diazinane - Monocyclic benzene moiety - Aryl halide - Aryl fluoride - Heteroaromatic compound - Tertiary carboxylic acid amide - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Carboxamide group - Azacycle - Nitrile - Carbonitrile - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as phenylquinolines. These are heterocyclic compounds containing a quinoline moiety substituted with a phenyl group. |
| External Descriptors | Not available |
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| Solubility | DMSO : 33.33 mg/mL (69.65 mM; Need ultrasonic) |
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