Necrosulfonamide - 10mM in DMSO , CAS No.1360614-48-7

CAS: 1360614-48-7 Cat. No.: N408273 Formula: C₁₈H₁₅N₅O₆S₂ Peso molecolare: 461.47

GRADE & PURITY 10mM in DMSO

Synonyms

2-​Propenamide, N-​[4-​[[(3-​methoxy-​2-​pyrazinyl)​amino]​sulfonyl]​phenyl]​-​3-​(5-​nitro-​2-​thienyl)​-​, (2E)​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Necrosulfonamide Necrosulfonamide is a very specific and potent necrosis inhibitor and blocks mixed lineage kinase domain-like protein (MLKL).
In vitro

Necrosulfonamide inhibits MLKL-mediated Necrosis by blocking its N-terminal CC domain function. It blocks necrosis downstream of RIP3 activation. Necrosulfonamide has no effect on apoptosis induced by TNF-α plus Smac mimetic in non-RIP3-expressing Panc-1 cells, even at 5 μM concentration. Necrosulfonamide efficiently blocks necrosis in human cells, but not mouse cells. The reason for the species specificity of necrosulfonamide is that the cysteine at residue 86 in human MLKL that is covalently modified by necrosulfonamide is replaced by a tryptophan residue in mouse MLKL(mixed lineage kinase domain-like protein).

In vivo

Cell Data

cell lines：

Concentrations：1 μM

Incubation Time：8 or 12 hrs

Powder Purity:≥99%

Specifications

Sinonimi

2-​Propenamide, N-​[4-​[[(3-​methoxy-​2-​pyrazinyl)​amino]​sulfonyl]​phenyl]​-​3-​(5-​nitro-​2-​thienyl)​-​, (2E)​-

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Necrosulfonamide is a very specific and potent necrosis inhibitor and blocks mixed lineage kinase domain-like protein (MLKL).

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Nomi e identificatori

• Isomeri SMILES: COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)/C=C/C3=CC=C(S3)[N+](=O)[O-]
• Peso molecolare: 461.47
• Reaxy-Rn: 30088938
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30088938&ln=

Proprietà chimiche e fisiche

• Punto di fusione (°C): 257 °C(dec.)

Riferimenti

1. Xue Shi, Yun Zhao, Hong-Yu Gao, Wei Yang, Jun Liao, Hui-Han Wang, Xiao-Tian Wang, Wei Yan.  (2025)  NFS1, together with FXN, protects cells from ferroptosis and DNA damage in diffuse large B-cell lymphoma.  Redox Biology,      [PMID:41005206] [10.1016/j.redox.2025.103878]

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1360614-48-7, the molecular formula is C18H15N5O6S2, and the molecular weight is 461.47 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.