≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
NEO2734 NEO2734 (EP31670) is a novel, orally active and selective dual inhibitor of p300/CBP and BET bromodomain with IC50 of both <30 nM.
Targets
p300/CBP (Cell-free assay); BET (Cell-free assay) <30 nM; <30 nM
In vitro
Treatment of NMC cells with the novel dual p300/CBP and BET bromodomain–selective inhibitor, NEO2734, potently inhibits growth and induces differentiation of NMC cells in vitro; findings that correspond with potentiated transcriptional effects from combined BET and p300 bromodomain inhibition.
In vivo
In three disseminated NMC xenograft models, NEO2734 provides greater growth inhibition, with tumor regression and significant survival benefit seen in two of three models, compared with a lead clinical BET inhibitor or “standard” chemotherapy.
Cell Research(from reference)
Cell lines：NUT carcinoma patient cell lines (TC-797, 14169, 10-15, PER-403)
Concentrations：1 μM
Incubation Time：24 h
| Pubchem Sid | 504773015 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504773015 |
| Sorrisi canonici | CC1=CC(=CN(C1=O)C)C2=CC3=C(C=C2)N=C(N3CCOC(F)(F)F)C4CCOCC4 |
| IUPAC Name | 1,3-dimethyl-5-[2-(oxan-4-yl)-3-[2-(trifluoromethoxy)ethyl]benzimidazol-5-yl]pyridin-2-one |
| InChIKey | KPWWFNXRLAAREN-UHFFFAOYSA-N |
| INCHI | 1S/C22H24F3N3O3/c1-14-11-17(13-27(2)21(14)29)16-3-4-18-19(12-16)28(7-10-31-22(23,24)25)20(26-18)15-5-8-30-9-6-15/h3-4,11-13,15H,5-10H2,1-2H3 |
| Peso molecolare | 435.44 |
| Reaxy-Rn | 30909951 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30909951&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | Data | Oggetto |
|---|---|---|---|
 F2218315 | Certificate of Analysis | Apr 03, 2025 | N414442 |
| F2218316 | Certificate of Analysis | Apr 03, 2025 | N414442 |
| F2218337 | Certificate of Analysis | Apr 03, 2025 | N414442 |
| F2218453 | Certificate of Analysis | Apr 03, 2025 | N414442 |
| Solubilità | Solubility (25°C) In vitro DMSO: 87 mg/mL (199.79 mM); Ethanol: 87 mg/mL (199.79 mM); Water: Insoluble; |
|---|---|
| Peso molecolare | 435.400 g/mol |
| XLogP3 | 2.900 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 5 |
| Exact Mass | 435.177 Da |
| Monoisotopic Mass | 435.177 Da |
| Topological Polar Surface Area | 56.600 Ų |
| Heavy Atom Count | 31 |
| Formal Charge | 0 |
| Complexity | 733.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
