NF-κΒ activator 2 - 10mM in DMSO , CAS No.2375281-44-8

CAS: 2375281-44-8 Cat. No.: N654597 Formula: C₁₆H₁₁FN₂O₃ Peso molecolare: 298.27 PubChem CID: 139434520

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

NF-κΒ activator 2 is a potent and orally active NF-ҡB activator, with an EC 50 of 1.58 μM. NF-κΒ activator 2 induces SOD 2 through increasing NF-ҡB expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS)

In Vitro

NF-κΒ activator 2 (compound 61) (1 μM, 6 h) induces SOD 2 mRNA expression in SH-SY5Y neuroblastoma cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NF-κΒ activator 2 (1 mg/kg; i.v.) displays a suitable half-life (0.96 h) in mice . NF-κΒ activator 2 (5 mg/kg; p.o.) displays a comparable half-life (2.86 h), oral bioavailability (15.6%), and C max (92 ng/mL) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:NF-κB 1.58 μM (EC 50 )

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

NF-κΒ activator 2 is a potent and orally active NF-ҡB activator, with an EC 50 of 1.58 μM. NF-κΒ activator 2 induces SOD 2 through increasing NF-ҡB expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

ACTIVATOR

Nomi e identificatori

• Isomeri SMILES: C1=CC=C(C(=C1)NC2=NC=C(O2)C3=CC(=CC=C3)C(=O)O)F
• PubChem CID: 139434520
• Peso molecolare: 298.27