Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
≥98% per flussi di lavoro cromatografici e analitici sensibili che richiedono un'interferenza minima della linea di base.
Store at -20°C,Argon charged Spedizione Ice chest + Ice pads. Consultare il COA specifico del lotto per le specifiche esatte.
SDS, COA, scheda tecnica e scheda delle specifiche disponibili per il download. COA specifico del lotto accessibile tramite ricerca per numero di lotto.
Citato in 0 pubblicazioni peer-reviewed su cromatografia, sintesi organica e reazioni di accoppiamento incrociato.
Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP) , a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase , ATP citrate lyase , and NPC1L1.
In Vitro
Nicodicosapent decreases the production of mature SREBP-2 protein in HepG2 cells, but does not interact with the GPR109A receptor. Nicodicosapent shows a synergistic inhibition on secreted PCSK9 and has an IC 50 value of 17 μM. Nicodicosapent significantly inhibits ApoB secretion in a dose-dependent manner with IC 50 of 27 μM. Nicodicosapent results in a time-dependent hydrolysis in HepG2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Nicodicosapent (100 mg/kg po) produces high plasma levels of nicotinuric acid in the plasma. ApoE*3-Leiden mice treated with Nicodicosapent show a significant reduction in PCSK9 levels, LDL particles including VLDL and LDL cholesterol, as well as plasma triglycerides . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
Documento completo su pericoli, manipolazione, stoccaggio e conformità normativa.
<<<<<<< HEAD Scarica SDS → ======= Scarica SDS → >>>>>>> release248-p3Dati di qualità specifici del lotto. Inserisci il numero di lotto per recuperare il COA esatto.
Cerca COA →Riepilogo di riferimento rapido delle specifiche e applicazioni del prodotto.
Visualizza scheda tecnica →Attributi di qualità completi e criteri di accettazione per questa qualità.
Visualizza scheda delle specifiche →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Classe | Pyridines and derivatives |
| Subclass | Pyridinecarboxylic acids and derivatives |
| Intermediate Tree Nodes | Pyridinecarboxamides |
| Direct Parent | Nicotinamides |
| Alternative Parents | N-acyl amines Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Nicotinamide - Fatty amide - N-acyl-amine - Fatty acyl - Heteroaromatic compound - Secondary carboxylic acid amide - Carboxamide group - Azacycle - Carboxylic acid derivative - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Aromatic heteromonocyclic compound |
| Descrizione | This compound belongs to the class of organic compounds known as nicotinamides. These are heterocyclic aromatic compounds containing a pyridine ring substituted at position 3 by a carboxamide group. |
| External Descriptors | Not available |
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Solubilità | DMSO : ≥ 100 mg/mL (222.41 mM) Ethanol : 2 mg/mL (4.45 mM; Need ultrasonic) |
|---|---|
| Peso molecolare | 449.600 g/mol |
| XLogP3 | 5.700 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 17 |
| Exact Mass | 449.304 Da |
| Monoisotopic Mass | 449.304 Da |
| Topological Polar Surface Area | 71.100 Ų |
| Heavy Atom Count | 33 |
| Formal Charge | 0 |
| Complexity | 662.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 5 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 5 |
| Covalently-Bonded Unit Count | 1 |
No tested application protocols are provided in the Product Data for this compound. The following general, non-item-specific guidance can help integrate a small-molecule library member into discovery workflows:
Always validate conditions on a small scale first and maintain traceability to lot number and preparation date. For item-specific protocols, consult the CoA/Spec Sheet.
No biological function or mechanism is specified in the Product Data for Nicodicosapent. Without a confirmed, public structural assignment and validated bioactivity annotations, it is inappropriate to attribute biological roles to this item in a catalog context.
Cautions on literature extrapolation:
For any intended biological study, consult the CoA/Spec Sheet for definitive identity information and perform minimal qualifying QC (e.g., LC–MS, NMR) before critical experiments.
This product is a discrete small molecule from a compound library and is not a buffering reagent. No buffer capacity, pKa, or formulation role is provided in the Product Data.
Item-specific buffer recipes or pH ranges are not applicable. Refer to your assay’s validated buffer system and verify compound compatibility empirically.
Green-chemistry substitution typically applies to solvents and common reagents. For a discrete screening compound like Nicodicosapent, greener alternatives are generally not applicable unless the compound is being used as a reagent or solvent (not indicated here). Nevertheless, you can apply green principles to the way you handle, analyze, and formulate the compound:
Example solvent comparison (general, non-item-specific):
Bottom line: Because this product is a specific small molecule (not a process solvent), the most meaningful green improvements come from solvent choices in your associated workflows, right-sizing experiments, and responsible waste handling.
No pharmacopeial status, excipient role, or manufacturing specification is provided for Nicodicosapent. This item is supplied strictly for research use only and is not intended for human or veterinary use, API manufacturing, or clinical applications.
No claims are made or implied regarding therapeutic utility, safety, or efficacy. For any application that demands compliance to pharmaceutical standards, obtain a compound with appropriate regulatory documentation.
Item-specific physicochemical data are not provided in the Product Data for Nicodicosapent. Do not assume specifications for method-critical parameters.
General guidance (non-spec, for planning only):
Important: Treat any property not explicitly stated here as unspecified for this specific item and consult the CoA/Spec Sheet for authoritative values. Do not translate literature values into specifications.
Item-specific grade and purity details are not present in the current Product Data. Do not infer analytical or chromatographic suitability without documentation.
Interpreting common grades (general guidance):
Recommended QC checks before critical use (best practices):
Note: Where grade/purity are critical to your workflow, please contact us for the latest CoA or a specification sheet for this exact lot.
Manufacturer Applications: Not provided in the Product Data for this item.
Given that Nicodicosapent is listed under a small-molecule/compound library category and no reactive functional groups are disclosed, detailed synthetic or reaction-chemistry applications cannot be asserted for this specific material. However, the following general research uses may apply to small-molecule library members (non-item-specific):
Practical tips (general best practices):
Note: For specific reaction chemistry (e.g., as a reagent, building block, or intermediate), structural details are required; consult the CoA/Spec Sheet.
No reaction-chemistry role is specified for Nicodicosapent, and the Product Data do not provide functional groups or reactivity patterns. As such, standard reaction conditions cannot be prescribed for this item.
General process guidance if you pursue derivatization (non-item-specific):
For any synthetic use, rely on your internal structure confirmation and stability studies; treat any condition ranges here as general organic-chemistry guidance, not item-specific instructions.
Safety data specific to this item are not included in the Product Data. Always consult the product’s SDS and institutional EHS guidance before handling.
Note: The above provides conservative, general-lab precautions. The SDS remains the authoritative source for hazard classification and response.
Solubility and solvent compatibility for this specific item are not stated in the Product Data. The guidance below is general and should be verified empirically for your application.
Small decision guide (general):
Always confirm final solvent choice by small pilot experiments and consult the CoA/Spec Sheet for any item-specific recommendations.
Item-specific storage conditions are provided; reconstitution specifics are not.
For any parameters not explicitly stated above (appearance, solubility, concentration limits, stability), treat them as unspecified for this item and consult the CoA/Spec Sheet or contact Aladdin Scientific for the latest lot-specific documentation.
Brief overview: Nicodicosapent is listed as a research-use small molecule in our compound library. Item-specific structural descriptors are not fully provided in the current Product Data.
Structural features (general guidance):
Notes for identity confirmation (general best practice):
Scope of data in this tab:
The Product Data do not disclose a structure, functional groups, or reactive handles for Nicodicosapent; therefore, specific synthetic transformations or building-block roles cannot be described for this item.
General notes for undefined small molecules (non-item-specific):
In the absence of an item-specific structure, treat this product as a finished research compound rather than a synthetic intermediate, unless your CoA/Spec Sheet and internal data support further derivatization.
Target specificity data (e.g., biochemical targets, binding partners, or cellular pathways) are not provided in the Product Data for Nicodicosapent.
Because this item is not an antibody or affinity reagent, attributes such as clone, isotype, species reactivity, or epitope are not applicable.