Nicodicosapent - ≥98% , CAS No.1269181-69-2

CAS: 1269181-69-2 Cat. No.: N648385 Formula: C28H39N3O2 Peso molecolare: 449.63 PubChem CID: 50991753
Disponibile su ordine
QUALITÀ & PUREZZA ≥98%
Synonyms
Nicodicosapent | N-(2-((5Z,8Z,11Z,14Z,17Z)-Icosa-5,8,11,14,17-pentaenamido)ethyl)pyridine-3-carboxamide | Nicodicosapent [INN] | UNII-72995E50VA | AKOS040742302 | MS-28152 | 3-Pyridinecarboxamide, N-(2-(((5Z,8Z,11Z,14Z,17Z)-1-oxo-5,8,11,14,17-eicosapentae
Storage
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
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Dimensione
Germania (EU)
USA*
Prezzo
Qtà
2mg
N648385-2mg
Su ordinazione · 8–12 settimane
174,33€
5mg
N648385-5mg
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313,17€
10mg
N648385-10mg
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521,42€
50mg
N648385-50mg
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1.562,71€
100mg
N648385-100mg
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2.604,00€
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Perché questa qualità

≥98% per flussi di lavoro cromatografici e analitici sensibili che richiedono un'interferenza minima della linea di base.

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Stoccaggio e spedizione

Store at -20°C,Argon charged Spedizione Ice chest + Ice pads. Consultare il COA specifico del lotto per le specifiche esatte.

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Documenti di qualità

SDS, COA, scheda tecnica e scheda delle specifiche disponibili per il download. COA specifico del lotto accessibile tramite ricerca per numero di lotto.

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Prova documentale

Citato in 0 pubblicazioni peer-reviewed su cromatografia, sintesi organica e reazioni di accoppiamento incrociato.

Panoramica

Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP) , a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase , ATP citrate lyase , and NPC1L1.

In Vitro

Nicodicosapent decreases the production of mature SREBP-2 protein in HepG2 cells, but does not interact with the GPR109A receptor. Nicodicosapent shows a synergistic inhibition on secreted PCSK9 and has an IC 50 value of 17 μM. Nicodicosapent significantly inhibits ApoB secretion in a dose-dependent manner with IC 50 of 27 μM. Nicodicosapent results in a time-dependent hydrolysis in HepG2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nicodicosapent (100 mg/kg po) produces high plasma levels of nicotinuric acid in the plasma. ApoE*3-Leiden mice treated with Nicodicosapent show a significant reduction in PCSK9 levels, LDL particles including VLDL and LDL cholesterol, as well as plasma triglycerides . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifiche

Sinonimi
Nicodicosapent | N-(2-((5Z,8Z,11Z,14Z,17Z)-Icosa-5,8,11,14,17-pentaenamido)ethyl)pyridine-3-carboxamide | Nicodicosapent [INN] | UNII-72995E50VA | AKOS040742302 | MS-28152 | 3-Pyridinecarboxamide, N-(2-(((5Z,8Z,11Z,14Z,17Z)-1-oxo-5,8,11,14,17-eicosapentae
Specifiche e purezza
≥98%
Meccanismi biochimici e fisiologici
Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP) , a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase , ATP citrate lyase , and NPC1L1.
Condizioni di conservazione di stoccaggio
Store at -20°C,Argon charged
Spedito in
Ice chest + Ice pads
Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.
Tipo di azione
INHIBITOR
Purezza
≥98%
Nomi e identificatori
Sorrisi canonici
CCC=CCC=CCC=CCC=CCC=CCCCC(=O)NCCNC(=O)C1=CN=CC=C1
IUPAC Name
N-[2-[[(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl]amino]ethyl]pyridine-3-carboxamide
InChIKey
YYQALOWPCKMFDQ-JLNKQSITSA-N
INCHI
1S/C28H39N3O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-21-27(32)30-23-24-31-28(33)26-20-19-22-29-25-26/h3-4,6-7,9-10,12-13,15-16,19-20,22,25H,2,5,8,11,14,17-18,21,23-24H2,1H3,(H,30,32)(H,31,33)/b4-3-,7-6-,10-9-,13-12-,16-15-
Isomeri SMILES
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCNC(=O)C1=CN=CC=C1
CAS alternativo
1269181-69-2
PubChem CID
50991753
Peso molecolare
449.63

Documentazione

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Dati avanzati

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassePyridines and derivatives
SubclassPyridinecarboxylic acids and derivatives
Intermediate Tree Nodes Pyridinecarboxamides
Direct ParentNicotinamides
Alternative Parents N-acyl amines  Heteroaromatic compounds  Secondary carboxylic acid amides  Azacyclic compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents Nicotinamide - Fatty amide - N-acyl-amine - Fatty acyl - Heteroaromatic compound - Secondary carboxylic acid amide - Carboxamide group - Azacycle - Carboxylic acid derivative - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Aromatic heteromonocyclic compound
DescrizioneThis compound belongs to the class of organic compounds known as nicotinamides. These are heterocyclic aromatic compounds containing a pyridine ring substituted at position 3 by a carboxamide group.
External Descriptors Not available
Struttura 3D
Modello di struttura chimica interattiva





Obiettivi associati (umani)
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver (3974 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Obiettivi associati (non umani)
Faah Anandamide amidohydrolase (3907 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hcar2 Hydroxycarboxylic acid receptor 2 (55 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Intestine (514 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Meccanismi d'azione
Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Proprietà chimiche e fisiche
SolubilitàDMSO : ≥ 100 mg/mL (222.41 mM) Ethanol : 2 mg/mL (4.45 mM; Need ultrasonic)
Peso molecolare449.600 g/mol
XLogP35.700
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count17
Exact Mass449.304 Da
Monoisotopic Mass449.304 Da
Topological Polar Surface Area71.100 Ų
Heavy Atom Count33
Formal Charge0
Complexity662.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count5
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds5
Covalently-Bonded Unit Count1
Calcolatori di soluzioni
Recensioni

Recensioni dei clienti

Application Protocols

No tested application protocols are provided in the Product Data for this compound. The following general, non-item-specific guidance can help integrate a small-molecule library member into discovery workflows:

  • Stock preparation:
    • Prepare concentrated stocks (e.g., 10–50 mM) in dry DMSO or another validated solvent once solubility is confirmed.
    • Filter sterilize through 0.2 µm (PTFE/nylon) if required by assay; verify no adsorption losses.
  • Aliquoting:
    • Dispense into single-use aliquots (amber vials/plates if light sensitivity is suspected) to avoid repeated freeze–thaw.
    • Maintain inert headspace where possible (argon backfill) consistent with item storage guidance.
  • Dilution into assay:
    • Add to buffers/cell media as the last step, keeping final organic co-solvent at the assay’s tolerated level (commonly ≤0.1–1% v/v DMSO).
    • Verify solution clarity and absence of precipitate over the assay duration.
  • Stability checks:
    • Run pre/post-assay LC–MS to confirm no significant degradation or adsorption.
    • Track plate/vial edge effects and evaporation if using high-throughput equipment.

Always validate conditions on a small scale first and maintain traceability to lot number and preparation date. For item-specific protocols, consult the CoA/Spec Sheet.

Biological Roles

No biological function or mechanism is specified in the Product Data for Nicodicosapent. Without a confirmed, public structural assignment and validated bioactivity annotations, it is inappropriate to attribute biological roles to this item in a catalog context.

  • Research Use Only: As stated, this material is supplied strictly for research use only. It is not for diagnostic, therapeutic, or clinical use.
  • Assay context (general): If your lab has independent knowledge of the structure and potential targets, validate activity using orthogonal assays (biochemical and cell-based) and confirm compound integrity under assay conditions (co-solvent level, pH, light/oxygen exposure).
  • ADME/T (exploratory, research-only): Where relevant to your internal program, perform basic stability and solubility screens and consider nonspecific binding (plasticware, serum proteins) as potential confounders in activity readouts.

Cautions on literature extrapolation:

  • Do not import literature bioactivity or target assignments for similarly named compounds as item-specific claims. Only use data generated with the exact same chemical identity, lot, and purity.

For any intended biological study, consult the CoA/Spec Sheet for definitive identity information and perform minimal qualifying QC (e.g., LC–MS, NMR) before critical experiments.

Buffer Applications

This product is a discrete small molecule from a compound library and is not a buffering reagent. No buffer capacity, pKa, or formulation role is provided in the Product Data.

  • If dissolution into aqueous systems is required for assays, use established biological buffers (e.g., PBS, HEPES, MOPS) and introduce the compound via a compatible co-solvent (e.g., 0.1–1% DMSO), verifying that precipitation does not occur.
  • For pH-sensitive compounds (unknown here), prepare fresh working solutions and minimize exposure to extremes of pH.

Item-specific buffer recipes or pH ranges are not applicable. Refer to your assay’s validated buffer system and verify compound compatibility empirically.

Green Alternatives

Green-chemistry substitution typically applies to solvents and common reagents. For a discrete screening compound like Nicodicosapent, greener alternatives are generally not applicable unless the compound is being used as a reagent or solvent (not indicated here). Nevertheless, you can apply green principles to the way you handle, analyze, and formulate the compound:

  • Solvent selection: Prefer greener solvents for processing/clean-up when feasible (e.g., ethanol, isopropanol, ethyl acetate) instead of chlorinated solvents, provided the compound’s solubility and stability permit.
  • Miniaturization: Reduce environmental footprint by running micro- to milliliter-scale assays and reactions, minimizing solvent consumption.
  • Energy use: Storage at −20 °C is item-specified; limit unnecessary bench-time and use insulated carriers to keep cold-chain energy effective.
  • Waste management: Segregate halogenated from non-halogenated organic waste; neutralize and dispose per local regulations and institutional EHS.

Example solvent comparison (general, non-item-specific):

  • Ethyl acetate vs dichloromethane: lower toxicity and environmental impact; test extraction efficiency first.
  • 2-Propanol vs methanol: lower acute toxicity; confirm analyte solubility and detector compatibility.

Bottom line: Because this product is a specific small molecule (not a process solvent), the most meaningful green improvements come from solvent choices in your associated workflows, right-sizing experiments, and responsible waste handling.

Pharmaceutical Uses

No pharmacopeial status, excipient role, or manufacturing specification is provided for Nicodicosapent. This item is supplied strictly for research use only and is not intended for human or veterinary use, API manufacturing, or clinical applications.

  • Regulatory status: Not specified for this item; refer to CoA/Spec Sheet. Do not assume compliance with USP/EP/JP or GMP.
  • Formulation context (research-only): If used in pre-formulation research, determine solubility in relevant vehicles (e.g., PEG400, ethanol, propylene glycol, Captisol) and verify chemical stability and photostability under your test conditions. Such work is exploratory and non-clinical.
  • Analytical controls: Develop stability-indicating methods (e.g., LC–MS) to monitor degradation during storage and handling.

No claims are made or implied regarding therapeutic utility, safety, or efficacy. For any application that demands compliance to pharmaceutical standards, obtain a compound with appropriate regulatory documentation.

Physical Properties

Item-specific physicochemical data are not provided in the Product Data for Nicodicosapent. Do not assume specifications for method-critical parameters.

  • Appearance: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular Formula: Not specified for this item; refer to CoA/Spec Sheet.
  • Melting/Freezing Point: Not specified for this item; refer to CoA/Spec Sheet.
  • Boiling Point: Not specified for this item; refer to CoA/Spec Sheet.
  • Density: Not specified for this item; refer to CoA/Spec Sheet.
  • Refractive Index: Not specified for this item; refer to CoA/Spec Sheet.
  • pKa/logP/logD: Not specified for this item; refer to CoA/Spec Sheet.
  • Water/Organic Solubility: Not specified for this item; refer to CoA/Spec Sheet.

General guidance (non-spec, for planning only):

  • Prior to use in analytical or screening workflows, determine solubility empirically in likely vehicles (e.g., DMSO, MeOH, EtOH, aqueous buffers with co-solvent) at your working concentrations.
  • For quantitative work, establish extinction coefficients or calibration curves by HPLC/UPLC-UV or LC–MS.
  • If the compound is sparingly soluble, consider stock solutions in anhydrous DMSO or ethanol and dilute into the working medium immediately before use to minimize precipitation.

Important: Treat any property not explicitly stated here as unspecified for this specific item and consult the CoA/Spec Sheet for authoritative values. Do not translate literature values into specifications.

Quality and Grades

Item-specific grade and purity details are not present in the current Product Data. Do not infer analytical or chromatographic suitability without documentation.

  • Grade / Purity: Not specified for this item; refer to CoA/Spec Sheet.
  • Stabilizers / Additives: Not specified for this item; refer to CoA/Spec Sheet.

Interpreting common grades (general guidance):

  • Research/Screening Grade: Typically suitable for discovery biology or medicinal chemistry screening; may not guarantee low non-volatile residue or low UV background.
  • Analytical (AR) / ACS Grade: Meets broader compositional criteria for wet chemistry; not necessarily optimized for LC/GC background.
  • HPLC/LC–MS Grade: Low particulates and low UV-absorbing/ionic impurities; intended mainly for solvents and select reagents.

Recommended QC checks before critical use (best practices):

  • Verify identity and purity by at least one orthogonal method (e.g., HPLC or LC–MS for % area, HRMS for exact mass, NMR for integrity/tautomer ratio).
  • Review vendor CoA for batch-specific purity, water content, and impurity profile (if available). For any parameter not listed on the CoA, treat it as unspecified.
  • If application demands are stringent (e.g., in vitro SAR, probe development), consider running stability studies (freeze–thaw, bench-top, and light exposure) to define handling windows.

Note: Where grade/purity are critical to your workflow, please contact us for the latest CoA or a specification sheet for this exact lot.

Reaction and Applications

Manufacturer Applications: Not provided in the Product Data for this item.

Given that Nicodicosapent is listed under a small-molecule/compound library category and no reactive functional groups are disclosed, detailed synthetic or reaction-chemistry applications cannot be asserted for this specific material. However, the following general research uses may apply to small-molecule library members (non-item-specific):

  • Screening and profiling: Use as part of HTS, target deconvolution, or phenotypic assays to explore structure–activity relationships (SAR) when identity and purity are verified.
  • Reference standard development: Establish LC–MS and HPLC methods (retention time, fragmentation patterns) to support quantification in discovery workflows.
  • Stability/Metabolism studies (in vitro): If the structure is known to your lab, investigate chemical stability (pH/light/oxidation) and exploratory microsomal or plasma stability for comparative profiling (research use only).
  • Formulation scouting for assays: Determine suitable stock vehicles (e.g., DMSO) and assay-compatible diluents.

Practical tips (general best practices):

  • Start with small-scale dissolved samples and confirm purity and stability after dissolution by LC–MS.
  • Minimize exposure to oxygen/moisture if the compound is supplied/stored under inert gas.
  • Document lot number and prepare single-use aliquots to reduce freeze–thaw cycles.

Note: For specific reaction chemistry (e.g., as a reagent, building block, or intermediate), structural details are required; consult the CoA/Spec Sheet.

Reaction Conditions

No reaction-chemistry role is specified for Nicodicosapent, and the Product Data do not provide functional groups or reactivity patterns. As such, standard reaction conditions cannot be prescribed for this item.

General process guidance if you pursue derivatization (non-item-specific):

  • Atmosphere: Given the specified storage under argon at −20 °C, conduct any transformations under inert gas with dry solvents until stability is established.
  • Solvents: Choose based on solubility and functional group compatibility (e.g., DCM/EtOAc for neutral organics, MeCN/THF/DMF/DMSO for polar substrates).
  • Temperatures: Start at 0–25 °C and escalate cautiously. Monitor by TLC/LC–MS.
  • Catalysts/Additives: Select per the functional groups present (e.g., coupling reagents for amide formation, bases for alkylations). None can be recommended specifically without a defined structure.
  • Workup/Purification: Use aqueous quench routes compatible with the compound’s stability profile; prefer flash chromatography or preparative HPLC for purification with light/oxygen protection if indicated.

For any synthetic use, rely on your internal structure confirmation and stability studies; treat any condition ranges here as general organic-chemistry guidance, not item-specific instructions.

Safety and Handling

Safety data specific to this item are not included in the Product Data. Always consult the product’s SDS and institutional EHS guidance before handling.

  • GHS Classification / Signal Word / H-Statements / Pictograms: Not specified for this item; refer to SDS.
  • Primary Risk Controls:
    • Use in a fume hood; avoid inhalation of dusts/aerosols if solid or mists/vapors if liquid.
    • Wear appropriate PPE: lab coat, nitrile gloves, splash goggles; upgrade PPE per SDS.
    • Avoid skin/eye contact and ingestion; practice good laboratory hygiene.
  • Storage Conditions (item-specific): Store at −20 °C, argon charged (as provided). Shipments are supplied on ice in an ice chest with ice pads. Minimize headspace air ingress on each use.
  • General Incompatibilities (general guidance): Absent structure-specific data, segregate from strong oxidizers and strong acids/bases until compatibility is confirmed.
  • Handling Tips:
    • If supplied under inert gas, open under dry inert atmosphere when feasible and promptly re-seal/flush with argon after use.
    • Use dry, oxygen-reduced solvents where stability is unknown; protect from excess heat and light.
  • First Aid (overview; consult SDS for details):
    • Eye/Skin: Rinse with water for ≥15 min; remove contaminated clothing; seek medical evaluation.
    • Inhalation: Move to fresh air, monitor respiration; seek medical attention if symptomatic.
    • Ingestion: Rinse mouth; do not induce vomiting unless directed by medical personnel; seek medical attention.

Note: The above provides conservative, general-lab precautions. The SDS remains the authoritative source for hazard classification and response.

Solvent Selection

Solubility and solvent compatibility for this specific item are not stated in the Product Data. The guidance below is general and should be verified empirically for your application.

  • Primary stock solvents to trial (general practice):
    • Anhydrous DMSO (first choice for small-molecule libraries)
    • Ethanol or Methanol for polar-to-moderately lipophilic compounds
    • Acetonitrile for LC compatibility and moderate polarity
    • Buffered aqueous media with co-solvent (1–10% DMSO/EtOH) if water solubility is limited
  • Miscibility considerations: Start with small-scale tests (e.g., 1–10 mg/mL) and visually inspect for clarity; follow with HPLC/UPLC to check for precipitation or decomposition after dilution.
  • pH and ionic strength: If ionizable groups are present (unknown here), aqueous solubility may vary strongly with pH; use minimal necessary organic co-solvent to meet assay constraints.
  • Water sensitivity: Storage guidance (−20 °C, argon) suggests caution with moisture and oxygen. Prefer freshly opened, dry solvents; minimize air exposure during solution prep.

Small decision guide (general):

  • Need highest solvating power and assay flexibility: DMSO.
  • LC–MS sample prep: ACN or MeOH (evaluate stability; filter through 0.2 µm PTFE/nylon as appropriate).
  • Bioassay dilution: Prepare concentrated DMSO stock (e.g., 10–50 mM), dilute into buffer immediately before use to avoid precipitation.

Always confirm final solvent choice by small pilot experiments and consult the CoA/Spec Sheet for any item-specific recommendations.

Storage and Reconstitution

Item-specific storage conditions are provided; reconstitution specifics are not.

  • Storage (as provided): Store at −20 °C, argon charged. Product is shipped in an ice chest with ice pads to maintain a cold chain.
  • Light/Oxygen/Moisture: The inert-gas requirement suggests sensitivity to oxygen and/or moisture. Protect from ambient air and consider amber containers to minimize light exposure until stability is known.
  • Container practices: Keep tightly sealed. After each use, backfill with argon, minimize headspace, and promptly return to cold storage.
  • Reconstitution:
    • Solvent and concentration: Not specified for this item; refer to CoA/Spec Sheet.
    • General approach: Dissolve the material in a validated solvent (commonly dry DMSO, MeOH, or EtOH) to prepare a concentrated stock solution. Vortex/sonicate briefly if needed; avoid prolonged heating.
    • Filtration: If particulate is observed, pass through a 0.2 µm PTFE/nylon filter; confirm no adsorption losses.
  • Aliquoting and stability: Prepare single-use aliquots to avoid freeze–thaw cycles. Record preparation date and store aliquots at −20 °C under argon.
  • Shelf life: Not specified for this item; refer to CoA/Spec Sheet.

For any parameters not explicitly stated above (appearance, solubility, concentration limits, stability), treat them as unspecified for this item and consult the CoA/Spec Sheet or contact Aladdin Scientific for the latest lot-specific documentation.

Structure and Identity

Brief overview: Nicodicosapent is listed as a research-use small molecule in our compound library. Item-specific structural descriptors are not fully provided in the current Product Data.

  • Product Name: Nicodicosapent
  • SKU: N648385
  • CAS: 1269181-69-2
  • PubChem CID: 50991753
  • InChIKey: 450356 (as provided; note: typical InChIKeys are 27 characters—consult CoA/SDS for the authoritative identifier)
  • SMILES: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular Formula: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.

Structural features (general guidance):

  • Specific functional groups, ring systems, and stereochemical information are not provided in the Product Data.
  • Without a supplied structure (SMILES/InChI), 2D/3D structural description cannot be authoritatively summarized here.

Notes for identity confirmation (general best practice):

  • Verify identity by vendor-supplied CoA/SDS and, if needed, orthogonal analytical methods (e.g., HRMS, 1H/13C NMR, HPLC/UPLC retention time match, IR).
  • Cross-check the CAS and CID in authoritative databases during method development.

Scope of data in this tab:

  • Item-specific facts above are taken directly from the Product Data. Any additional structural/literature detail should be sourced from the CoA/Spec Sheet or primary databases for this CAS.
Synthetic Utility

The Product Data do not disclose a structure, functional groups, or reactive handles for Nicodicosapent; therefore, specific synthetic transformations or building-block roles cannot be described for this item.

General notes for undefined small molecules (non-item-specific):

  • If the structure is known within your program, map functional handles (e.g., carboxylic acids, amines, halides, alkenes) and plan derivatization (amide coupling, alkylation/arylation, hydrogenation/oxidation) accordingly.
  • For library expansion, consider diversity-oriented modifications around pharmacophores (if applicable) and validate each transformation by LC–MS and NMR.
  • If the compound is sensitive to oxygen, moisture, or light (storage suggests inert handling), favor mild conditions, degassed solvents, and darkened glassware during manipulations.

In the absence of an item-specific structure, treat this product as a finished research compound rather than a synthetic intermediate, unless your CoA/Spec Sheet and internal data support further derivatization.

Target Specificity

Target specificity data (e.g., biochemical targets, binding partners, or cellular pathways) are not provided in the Product Data for Nicodicosapent.

  • No claims are made regarding molecular targets, selectivity profiles, or potency.
  • If your research aims to profile activity, employ broad screening panels and orthogonal confirmation assays. Include controls for assay interference (aggregation, redox cycling, fluorescence quenching) and confirm compound integrity by LC–MS before and after assay.

Because this item is not an antibody or affinity reagent, attributes such as clone, isotype, species reactivity, or epitope are not applicable.

Domande frequenti

What is the purity of this product?
This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
How should this product be stored?
Store at ?20 °C under argon. It is supplied under an argon blanket; reseal under inert gas after each use.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 1269181-69-2, the molecular formula is C28H39N3O2, and the molecular weight is 449.63 g/mol. InChIKey YYQALOWPCKMFDQ-JLNKQSITSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

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