Idrazide nicotinica - ≥98% , CAS No.553-53-7

CAS: 553-53-7 Cat. No.: N109733 Formula: C₆H₇N₃O Peso molecolare: 137.14 Beilstein Registry Number: 119299 Numero EC: 209-041-0

GRADE & PURITY ≥98%

Synonyms

MFCD00006383 | Idrazide dell'acido nicotinico | HY-W012617 | Niazid | BB 0240607 | EN300-18499 | FT-0632378 | (3-Piridilcarbonil)idrazina | Nicotinoidrazide | SY033050 | 3-Piridilcarbonilidrazina | F0001-1451 | NCGC00248790-01 | AF1LLO72TM | ACIDO NICOTIN

Storage

Conservare a 2-8°C, con carica di argon

Shipped In

Ghiaccio umido

Panoramica

L'idrazide nicotinica si scioglie in acqua alla concentrazione di 50 mg/ml formando una soluzione limpida e incolore.

L'idrazide nicotinica viene utilizzata per la formazione di librerie di idrazoni. Viene utilizzato per studiare l'ossidazione dell'idrazide dell'acido isonicotinico (ionizzato) da parte della perossidasi di rafano. L'idrazide nicotinica è un inibitore dell'enzima perossidasi. Forma complessi metallici solidi con forte attività biologica

Specifications

Sinonimi

MFCD00006383 | Idrazide dell'acido nicotinico | HY-W012617 | Niazid | BB 0240607 | EN300-18499 | FT-0632378 | (3-Piridilcarbonil)idrazina | Nicotinoidrazide | SY033050 | 3-Piridilcarbonilidrazina | F0001-1451 | NCGC00248790-01 | AF1LLO72TM | ACIDO NICOTIN

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

L'idrazide nicotinica è un inibitore dell'enzima perossidasi. Forma complessi metallici solidi con forte attività biologica.

Condizioni di conservazione di stoccaggio

Conservare a 2-8°C, con carica di argon

Spedito in

Ghiaccio umido

Purezza

≥98%

Nomi e identificatori

• Pubchem Sid: 504752064
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504752064
• Sorrisi canonici: C1=CC(=CN=C1)C(=O)NN
• IUPAC Name: pyridine-3-carbohydrazide
• InChIKey: KFUSANSHCADHNJ-UHFFFAOYSA-N
• INCHI: 1S/C6H7N3O/c7-9-6(10)5-2-1-3-8-4-5/h1-4H,7H2,(H,9,10)
• Isomeri SMILES: C1=CC(=CN=C1)C(=O)NN
• WGK Germania: 3
• RTECS: QT1750000
• Peso molecolare: 137.14
• Beilstein: 119299
• Reaxy-Rn: 119299
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=119299&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Pyridines and derivatives
      • Subclass Pyridinecarboxylic acids and derivatives
        • Level5 Pyridinecarboxamides
          • Level6 Nicotinamides

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Pyridines and derivatives
• Subclass: Pyridinecarboxylic acids and derivatives
• Intermediate Tree Nodes: Pyridinecarboxamides
• Direct Parent: Nicotinamides
• Alternative Parents: Heteroaromatic compounds Carboxylic acid hydrazides Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Nicotinamide - Heteroaromatic compound - Carboxylic acid hydrazide - Azacycle - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteromonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as nicotinamides. These are heterocyclic aromatic compounds containing a pyridine ring substituted at position 3 by a carboxamide group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

HepG2 (196354 Activities)

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Obiettivi associati (non umani)

Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Bacillus subtilis (32866 Activities)

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Mycobacterium tuberculosis (203094 Activities)

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Plasmodium falciparum (966862 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Trypanosoma cruzi (99888 Activities)

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Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: Soluble in alcohol, water.
• Sensibilità: Air sensitive
• Punto di fusione (°C): 160-163°C
• Peso molecolare: 137.140 g/mol
• XLogP3: -0.700
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 137.059 Da
• Monoisotopic Mass: 137.059 Da
• Topological Polar Surface Area: 68.000 Ų
• Heavy Atom Count: 10
• Formal Charge: 0
• Complexity: 126.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Riferimenti

1. Zuobing Xiao, Chengjing Wu, Xinyu Lu, Yunwei Niu, Peiran Yu, Xiaojie Ma.  (2023)  Substituent effect on controlled release of fragrant aldehydes from pH-triggered nicotinoylhydrazone-based precursors.  Molecular Systems Design & Engineering,  8  (6): (767-774).  [PMID:] [10.1039/D2ME00279E]

2. Min Xue, Yanchao Lü, Qingqing Sun, Kaiqiang Liu, Zhen Liu, Ping Sun.  (2015)  Ag(I)-Coordinated Supramolecular Metallogels Based on Schiff Base Ligands: Structural Characterization and Reversible Thixotropic Property.  CRYSTAL GROWTH & DESIGN,      [PMID:] [10.1021/acs.cgd.5b00952]