NITD-688 - ≥99% , CAS No.2407227-31-8

CAS: 2407227-31-8 Cat. No.: N651789 Formula: C₂₅H₃₂N₄O₃S₂ Peso molecolare: 500.68 PubChem CID: 146279852

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV)

In Vitro

NITD-688 shows antiviral activity against all four serotypes of dengue virus (DENV), with EC 50 values of 8 to 38 nM. NITD-688 shows antiviral activity against DENV-2 infected PBMCs, with an EC 50 value of 0.94 nM. NITD-688 directly binds to wild-type but not mutant NS4B protein. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NITD-688 (30 mg/kg, oral gavage, twice daily for 3 days) demonstrates excellent antiviral efficacy in infected AG129 mice . NITD-688 (15-300 mg/kg, oral gavage, per day for 7 days) is well tolerated in rats and dogs (toxicology studies) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Infected AG129 mice Dosage: 30 mg/kg Administration: Oral gavage, twice daily for 3 days Result: Resulted in a 1.16-log reduction in viremia.

Form:Solid

IC50& Target:NS4B

Specifications

Specifiche e purezza

≥99%

Meccanismi biochimici e fisiologici

NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV).

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Purezza

≥99%

Nomi e identificatori

• Isomeri SMILES: CC1(CC2=C(CN1CC3CCCCC3)C(=C(S2)NC(=O)CC4=CC=C(C=C4)S(=O)(=O)N)C#N)C
• PubChem CID: 146279852
• Peso molecolare: 500.68

Proprietà chimiche e fisiche

• Solubilità: DMSO : 100 mg/mL (199.73 mM; ultrasonic and warming and heat to 60°C)

Domande frequenti

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2407227-31-8, the molecular formula is C25H32N4O3S2, and the molecular weight is 500.68 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.