NMDI14 - 10mM in DMSO , CAS No.307519-88-6

CAS: 307519-88-6 Cat. No.: N655628 Formula: C₂₁H₂₅N₃O₄S Peso molecolare: 415.51 PubChem CID: 2886617

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

NMDI14 is a nonsense mediated RNA decay ( NMD ) inhibitor. NMDI14 disrupts the SMG7-UPF1 interactions and inhibits NMD .

In Vitro

NMDI14 is a nonsense mediated RNA decay (NMD) inhibitor. Treating cells with NMDI14 for 6 hours leads to an increase of PTC 39 β globin to 12%, a relative four-fold increase that, if resulting in biologically active hemoglobin, would be sufficient to ameliorate the clinical symptoms of thalassemia. Three days of treatment with NMDI14 results in no decrease in cell counts, demonstrating that the pharmacological inhibition of NMD can be achieved without subtle changes in proliferation. 941 genes are increased >1.5 fold with NMDI14. The treatment of N417 cells with NMDI14 for 6 hours leads to a steady state expression of p53 similar to that seen in U2OS cells. NMDI14 significantly increases the stability of PTC mutated p53 mRNA in N417 cells, without altering the stability of wild-type p53 in NMDI treated U2OS cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:NMD

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

NMDI14 is a nonsense mediated RNA decay ( NMD ) inhibitor. NMDI14 disrupts the SMG7-UPF1 interactions and inhibits NMD .

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

• Isomeri SMILES: CCOC(=O)C1=C(SC(=C1C)C)NC(=O)CC2C(=O)NC3=C(N2)C=C(C(=C3)C)C
• PubChem CID: 2886617
• Peso molecolare: 415.51

Domande frequenti

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 307519-88-6, the molecular formula is C21H25N3O4S, and the molecular weight is 415.51 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.