noradrenaline - Moligand™,≥98% , Agonist of β 1-adrenoceptor;Agonist of β 2-adrenoceptor;Agonist of D 1 receptor;Agonist of D 5 receptor, CAS No.138-65-8, Agonist of β 1-adrenoceptor;Agonist of β 2-adrenoceptor;Agonist of D 1 receptor;Agonist of D 5 receptor

CAS: 138-65-8 Cat. No.: N612358 Numero EC: 205-337-9 PubChem CID: 951

GRADE & PURITY Moligand™, ≥98%

Synonyms

NCGC00185992-01 | (.+/-.)-Arterenol | HR-0338 | AC-10030 | EINECS 205-337-9 | Noradrop | NSC294898 | NSC-294898 | 4-(2-amino-1-hydroxy-ethyl)benzene-1,2-diol | 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol | CHEBI:33569 | CCG-204148 | DL-[7-3H]norepinephrine

Storage

Store at 2-8°C

Shipped In

Wet ice

Specifications

Sinonimi

NCGC00185992-01 | (.+/-.)-Arterenol | HR-0338 | AC-10030 | EINECS 205-337-9 | Noradrop | NSC294898 | NSC-294898 | 4-(2-amino-1-hydroxy-ethyl)benzene-1,2-diol | 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol | CHEBI:33569 | CCG-204148 | DL-[7-3H]norepinephrine

Specifiche e purezza

Moligand™,≥98%

Condizioni di conservazione di stoccaggio

Store at 2-8°C

Spedito in

Wet ice

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

AGONIST

Meccanismo d'azione

Agonist of β 1-adrenoceptor;Agonist of β 2-adrenoceptor;Agonist of D 1 receptor;Agonist of D 5 receptor

Purezza

≥98%

Nomi e identificatori

• Sorrisi canonici: NCC(c1ccc(c(c1)O)O)O
• IUPAC Name: 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol
• InChIKey: SFLSHLFXELFNJZ-UHFFFAOYSA-N
• INCHI: 1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2
• Isomeri SMILES: C1=CC(=C(C=C1C(CN)O)O)O
• PubChem CID: 951

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Phenols
      • Subclass Benzenediols

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Phenols
• Subclass: Benzenediols
• Intermediate Tree Nodes: Not available
• Direct Parent: Catechols
• Alternative Parents: Aralkylamines 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Benzene and substituted derivatives Secondary alcohols 1,2-aminoalcohols Organopnictogen compounds Monoalkylamines Hydrocarbon derivatives Aromatic alcohols
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Catechol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Aralkylamine - Monocyclic benzene moiety - 1,2-aminoalcohol - Secondary alcohol - Organic nitrogen compound - Aromatic alcohol - Hydrocarbon derivative - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Organopnictogen compound - Organic oxygen compound - Amine - Alcohol - Aromatic homomonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as catechols. These are compounds containing a 1,2-benzenediol moiety.
• External Descriptors: catecholamine

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

DRD1 Tclin D(1A) dopamine receptor (1 Activities)

Discover Target: DRD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD5 Tchem D(1B) dopamine receptor (1 Activities)

Discover Target: DRD5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRB2 Tclin Beta-2 adrenergic receptor (1 Activities)

Discover Target: ADRB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRB1 Tclin Beta-1 adrenergic receptor (1 Activities)

Discover Target: ADRB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD1 Tclin Dopamine D1 receptor (9720 Activities)

Discover Target: DRD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FEN1 Tchem Flap endonuclease 1 (12055 Activities)

Discover Target: FEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLK Tbio DNA polymerase kappa (8653 Activities)

Discover Target: POLK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

Discover Target: ATAD5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Obiettivi associati (non umani)

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Taar1 Trace amine-associated receptor 1 (899 Activities)

Discover Target: Taar1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

pfk 6-phospho-1-fructokinase (7870 Activities)

Discover Target: pfk

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Phosphoglycerate kinase, glycosomal (2184 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Adra1b Adrenergic receptor alpha (950 Activities)

Discover Target: Adra1b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione

Proprietà chimiche e fisiche

• Peso molecolare: 169.180 g/mol
• XLogP3: -1.200
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 169.074 Da
• Monoisotopic Mass: 169.074 Da
• Topological Polar Surface Area: 86.700 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 142.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Riferimenti

1. Lin Liu, Guifang Wang, Qingqin Feng, Yun Xing, Hongxing Han, Min Jing.  (2023)  Specific and Amplified Voltammetric Detection of Dopamine at Nitrilotriacetic acid-Iron Modified Gold Electrode.  International Journal of Electrochemical Science,      [PMID:] [10.1016/S1452-3981(23)14433-6]

2. Zhenzhen Zhang, Lingling Yang, Ya Li, Di Sun, Rong Chen, Shengqian Dou, Ting Liu, Sai Zhang, Qingjun Zhou, Lixin Xie.  (2023)  Interference of sympathetic overactivation restores limbal stem/progenitor cells function and accelerates corneal epithelial wound healing in diabetic mice.  BIOMEDICINE & PHARMACOTHERAPY,      [PMID:36931034] [10.1016/j.biopha.2023.114523]

3. Fang-Nan Wu, Jian Zhu, Guo-Jun Weng, Jian-Jun Li, Xue-Wu Chen, Jun-Wu Zhao.  (2023)  Electron transfer-based norepinephrine detection with high sensitivity regulated by polyethyleneimine molecular weight.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2023.133297]

4. Huang Yue, Wu Xiangyan, Wu Meizhu, Chu Jianfeng, Yu Na, Shen Aling, Shen Zhiqing, Chen Youqin, Peng Jun.  (2019)  Antihypertensive and Vasodilatory Effects of Qingda Granules by Suppression of Calcium Influx and the AKT Pathway.  JOURNAL OF CARDIOVASCULAR PHARMACOLOGY,  74  (6): (549).  [PMID:31809404] [10.1097/FJC.0000000000000686]

5. Yijia Tang, Siming Huang, Jianqiao Xu, Gangfeng Ouyang, Yuan Liu.  (2018)  PLGA-based nanofibers with a biomimetic polynoradrenaline sheath for rapid in vivo sampling of tetrodotoxin and sulfonamides in pufferfish.  Journal of Materials Chemistry B,  6  (22): (3655-3664).  [PMID:32254828] [10.1039/C8TB00757H]

6. Xiao Deli, Liu Shubo, Liang Liyun, Bi Yanping.  (2016)  Magnetic restricted-access microspheres for extraction of adrenaline, dopamine and noradrenaline from biological samples.  MICROCHIMICA ACTA,  183  (4): (1417-1423).  [PMID:] [10.1007/s00604-016-1768-9]

7. Tao Qian, Chenfei Yu, Xi Zhou, Shishan Wu, Jian Shen.  (2013)  Au nanoparticles decorated polypyrrole/reduced graphene oxide hybrid sheets for ultrasensitive dopamine detection.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2013.12.055]

8. Yifei Ma, Lijie Zhang, Hong Yang, Shanshan Zhu, Jinhua Liu.  (2025)  Imidazole-triggered in situ fluorescence reaction system for quantitatively determination of dopamine from multiple sources.  TALANTA,      [PMID:40157196] [10.1016/j.talanta.2025.127975]

9. Baoting Dou, Hui Shen, Zhimin Li, Huanyu Cheng, Po Wang.  (2025)  Chemically modified DNAzymes-based electrochemical sensor for binary and highly sensitive detection of reactive oxygen species.  Chemical Science,      [PMID:39867952] [10.1039/D4SC05512H]

10. Jiamin Gong, Boran Zhang, Qinyi Li, Jiangli Shi, Xinling Liu, Yiping Wu, Ying Wen, Xiaoyu Guo, Haifeng Yang.  (2025)  Three-dimensional AuNRs/MXene/NFs -based SERS platform for determination of quetiapine in urine.  TALANTA,      [PMID:40239585] [10.1016/j.talanta.2025.128157]

Domande frequenti

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at 2–8 °C. Refrigerated storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 138-65-8. InChIKey SFLSHLFXELFNJZ-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.