Nrf2-IN-1 - Moligand™,10mM in DMSO , CAS No.1610022-76-8

CAS: 1610022-76-8 Cat. No.: N656894 Formula: C₂₁H₂₂ClN₃O₂ Peso molecolare: 383.87 PubChem CID: 76900951

GRADE & PURITY Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2) . Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML)

In Vitro

Nrf2-IN-1 (Compound 4f) (10 μM) inhibits Nrf2 activation. ?\nNrf2-IN-1(1-20 μM; 48 hours) inhibits growth of the three AML cell. ?\nNrf2-IN-1 (5-10 μM; 48 hours) induces apoptosis of three AML cells in vitro. ?\nNrf2-IN-1 induces apoptotic signaling involving Bcl-2 and Bax. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: THP-1 cells, HL-60 cells, U937 cells Concentration: 1 μM, 5 μM, 10 μM, 20 μM Incubation Time: 48 hours Result: Inhibited growth of the three AML cell types at 5 μM, 10 μM or 20 μM for 48 hours. Apoptosis AnalysisCell Line: THP-1 cells, HL-60 cells, U937 cells Concentration: 5 μM, 10 μM Incubation Time: 48 hours Result: Induced apoptosis in AML cells in vitro. Western Blot AnalysisCell Line: THP-1 cells, HL-60 cells, U937 cells Concentration: 5 μM, 10 μM Incubation Time: 48 hours Result: Triggered caspase-dependent apoptotic signaling in AML cells.

In Vivo

Nrf2-IN-1 inhibits tumor growth via apoptosis in chicken eggs . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Nrf2

Specifications

Specifiche e purezza

Moligand™,10mM in DMSO

Meccanismi biochimici e fisiologici

Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2) . Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Nomi e identificatori

• Isomeri SMILES: CC(C)(C)C1=CC=C(C=C1)CN2C(=CC(=N2)C3=CC=C(C=C3)Cl)C(=O)NO
• PubChem CID: 76900951
• Peso molecolare: 383.87

Domande frequenti

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1610022-76-8, the molecular formula is C21H22ClN3O2, and the molecular weight is 383.87 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.