NS 11021 - Moligand™, ≥95% , Activator of K Ca1.1, CAS No.956014-19-0, Activator of K Ca1.1

CAS: 956014-19-0 Cat. No.: N287933 Formula: C₁₆H₉BrF₆N₆S Peso molecolare: 511.24 Numero EC: 804-729-2

GRADE & PURITY Moligand™, ≥95%

Synonyms

1-[3,5-bis(trifluoromethyl)phenyl]-3-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]thiourea. | NS 11021 | AC-36032 | BCP16316 | HY-13103 | EX-A744 | 3,3'-Diindolylmethane (DIM) | SCHEMBL19212168 | OGAKLTJNUQRZJU-UHFFFAOYSA- | DIFLUNISAL (MART.) | 1-(3,5-Bis-trifluo

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Sinonimi

1-[3,5-bis(trifluoromethyl)phenyl]-3-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]thiourea. | NS 11021 | AC-36032 | BCP16316 | HY-13103 | EX-A744 | 3,3'-Diindolylmethane (DIM) | SCHEMBL19212168 | OGAKLTJNUQRZJU-UHFFFAOYSA- | DIFLUNISAL (MART.) | 1-(3,5-Bis-trifluo

Specifiche e purezza

Moligand™, ≥95%

Meccanismi biochimici e fisiologici

Activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+(KV), Na+and Ca2+currents at concentrations <10μM. Alters gating kinetics, but does not affect single channel conductance. Sho

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

ACTIVATOR

Meccanismo d'azione

Activator of K Ca1.1

Purezza

≥95%

Nomi e identificatori

• Pubchem Sid: 528766309
• Sorrisi canonici: C1=CC(=C(C=C1Br)C2=NNN=N2)NC(=S)NC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
• IUPAC Name: 1-[3,5-bis(trifluoromethyl)phenyl]-3-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]thiourea
• InChIKey: MDKAFDIKYQMOMF-UHFFFAOYSA-N
• INCHI: 1S/C16H9BrF6N6S/c17-9-1-2-12(11(6-9)13-26-28-29-27-13)25-14(30)24-10-4-7(15(18,19)20)3-8(5-10)16(21,22)23/h1-6H,(H2,24,25,30)(H,26,27,28,29)
• Isomeri SMILES: C1=CC(=C(C=C1Br)C2=NNN=N2)NC(=S)NC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
• Peso molecolare: 511.24
• Reaxy-Rn: 31540432
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31540432&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Azoles
      • Subclass Tetrazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Azoles
• Subclass: Tetrazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenyltetrazoles and derivatives
• Alternative Parents: Trifluoromethylbenzenes N-phenylthioureas Bromobenzenes Aryl bromides Heteroaromatic compounds Thioureas Azacyclic compounds Organonitrogen compounds Organofluorides Organobromides Hydrocarbon derivatives Alkyl fluorides
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Phenyltetrazole - Trifluoromethylbenzene - N-phenylthiourea - Bromobenzene - Halobenzene - Aryl bromide - Aryl halide - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Thiourea - Azacycle - Organonitrogen compound - Organofluoride - Organobromide - Organohalogen compound - Hydrocarbon derivative - Organic nitrogen compound - Alkyl halide - Organosulfur compound - Alkyl fluoride - Aromatic heteromonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as phenyltetrazoles and derivatives. These are compounds containing a phenyltetrazole skeleton, which consists of a tetrazole bound to a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

KCNMA1 Tclin Calcium-activated potassium channel subunit alpha-1 (0 Activities)

Discover Target: KCNMA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Obiettivi associati (non umani)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: Solvent:ethanol, Max Conc. mg/mL: 51.12, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 51.12, Max Conc. mM: 100
• Peso molecolare: 511.200 g/mol
• XLogP3: 4.800
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 3
• Exact Mass: 509.97 Da
• Monoisotopic Mass: 509.97 Da
• Topological Polar Surface Area: 111.000 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 586.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1