NS309 - Moligand™, 10mM in DMSO , Activator of K Ca2.1;Activator of K Ca2.2;Activator of K Ca2.3;Activator of K Ca3.1, CAS No.18711-16-5, Activator of K Ca2.1;Activator of K Ca2.2;Activator of K Ca2.3;Activator of K Ca3.1

CAS: 18711-16-5 Cat. No.: N422287 Formula: C₈H₄Cl₂N₂O₂ Peso molecolare: 231.04 Numero EC: 633-759-7 PubChem CID: 135502903

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

AKOS024457856 | F84856 | NS309 | NS-309 | AKOS025248274 | NS309, >=98% (HPLC), solid | (e)-6,7-dichloro-3-(hydroxyimino)indolin-2-one | 2-(aminomethyl)-4-(7-chloroquinolin-4-ylamino)phenol;NS-309 | 3-Oxime-6,7-dichloro-1H-indole-2,3-dione | (Z)-6,7-dichlo

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

NS309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.
A Ca2+-activated IK/SK potassium channel activator

Specifications

Sinonimi

AKOS024457856 | F84856 | NS309 | NS-309 | AKOS025248274 | NS309, >=98% (HPLC), solid | (e)-6,7-dichloro-3-(hydroxyimino)indolin-2-one | 2-(aminomethyl)-4-(7-chloroquinolin-4-ylamino)phenol;NS-309 | 3-Oxime-6,7-dichloro-1H-indole-2,3-dione | (Z)-6,7-dichlo

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

Potent activator of human Ca 2+ -activated K + channels of SK and IK types, selective over BK type channels (EC 50 = 10 nM for increasing hIK current). At least 1000 times more potent than 1-EBIO .

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

ACTIVATOR

Meccanismo d'azione

Activator of K Ca2.1;Activator of K Ca2.2;Activator of K Ca2.3;Activator of K Ca3.1

Nomi e identificatori

• Pubchem Sid: 528766316
• Sorrisi canonici: C1=CC(=C(C2=C1C(=C(N2)O)N=O)Cl)Cl
• IUPAC Name: 6,7-dichloro-3-nitroso-1H-indol-2-ol
• InChIKey: ROBYKNONIPZMTK-UHFFFAOYSA-N
• INCHI: 1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,11,13H
• Isomeri SMILES: C1=CC(=C(C2=C1C(=C(N2)O)N=O)Cl)Cl
• WGK Germania: 2
• PubChem CID: 135502903
• Peso molecolare: 231.04

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Indoles and derivatives
      • Subclass Hydroxyindoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Indoles and derivatives
• Subclass: Hydroxyindoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Hydroxyindoles
• Alternative Parents: Indoles Substituted pyrroles Benzenoids Aryl chlorides Heteroaromatic compounds Propargyl-type 1,3-dipolar organic compounds C-nitroso compounds Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organochlorides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Hydroxyindole - Indole - Benzenoid - Substituted pyrrole - Aryl halide - Aryl chloride - Heteroaromatic compound - Pyrrole - Organic nitroso compound - Azacycle - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - C-nitroso compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as hydroxyindoles. These are organic compounds containing an indole moiety that carries a hydroxyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

KCNN4 Tchem Intermediate conductance calcium-activated potassium channel protein 4 (1 Activities)

Discover Target: KCNN4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNN1 Tchem Small conductance calcium-activated potassium channel protein 1 (0 Activities)

Discover Target: KCNN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNN3 Tchem Small conductance calcium-activated potassium channel protein 3 (0 Activities)

Discover Target: KCNN3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNN2 Tchem Small conductance calcium-activated potassium channel protein 2 (1 Activities)

Discover Target: KCNN2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Peso molecolare: 231.030 g/mol
• XLogP3: 3.200
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 229.965 Da
• Monoisotopic Mass: 229.965 Da
• Topological Polar Surface Area: 65.500 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 241.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1