ODN 1585 - ≥93% , CAS No.386832-46-8

CAS: 386832-46-8 Cat. No.: O646977 Peso molecolare: 6430.00

GRADE & PURITY ≥93%

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Panoramica

ODN 1585 is a potent inducer of IFN and TNFα production. ODN 1585 is a potent stimulator of NK (natural killer) function. ODN 1585 increases CD8+ T-cell function, including the CD8+ T cell-mediated production of IFN-γ. ODN 1585 induces regression of established melanomas in mice. ODN 1585 can confer complete protection against malaria in mice. ODN 1585 can be used for acute myelogenous leukemia (AML) and malaria research. ODN 1585 can be used as a vaccine adjuvant .

In Vitro

ODN 1585 (3 μg/mL, 48 h) induces PBMC producing IFN-α in the nanogram range. ODN 1585 increases the percentage of CD69+ (early marker of activation) NK cells within 24 h (26±7%). CpG ODN (0.6μg/mL, 18 h) stimulates NK cell-mediated lysis of K562 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ODN 1585 (50-500 μg, Injection into the tibialis anterior muscle, single) protects 20 to 90% of mice from sporozoite infection . ODN 1585 (100 μg/dose, IP, twice weekly) is determined to be optimal for the induction of antitumor responses in several systems involving comparisons of 30, 100, and 300 μg/injection. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: BALB/c ByJ mice (4- to 8-week-old, female, 6-18 mice in each group) Dosage: 50, 100, 200, or 500 μg (in 50 μL of saline) Administration: Injection into the tibialis anterior muscle, single (at 7, 2, or 1 day(s) prior to sporozoite infection, on the day of infection, and/or at 1 day postinfection) Result: Protected 20 to 90% of mice from infection when the ODN 1585 was administered around the time of sporozoite challenge with doses of 50 to 500 μg. The highest level of protection (90%) resulted from administration of 200 μg of CpG ODN 1585 the day before challenge or 100 μg of CpG ODN 1585 on the day before and the day of challenge.

Form:Solid

Specifications

Specifiche e purezza

≥93%

Meccanismi biochimici e fisiologici

ODN 1585 is a potent inducer of IFN and TNFα production. ODN 1585 is a potent stimulator of NK (natural killer) function. ODN 1585 increases CD8+ T-cell function, including the CD8+ T cell-mediated production of IFN-γ . ODN 1585 induces regression of esta

Condizioni di conservazione di stoccaggio

Store at -20°C,Desiccated

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Purezza

≥93%

Nomi e identificatori

• Sorrisi canonici: [DNA, d(G-sp-G-G-G-T-C-A-A-C-G-T-T-G-A-G-G-sp-G-sp-G-sp-G-sp-G)]
• Peso molecolare: 6430.00

Proprietà chimiche e fisiche

• Solubilità: H2O : 20 mg/mL (3.11 mM; Need ultrasonic)

Domande frequenti

What is the purity of this product?

This product is supplied at ≥93% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 386832-46-8, and the molecular weight is 6430.00 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.