≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
ONO-4059 analogue ONO-4059 analogue (ONO-WG-307) is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1.
Targets
BTK 23.9 nM
In vitro
In TMD-8 cells, ONO-4059 inhibits cell growth with IC50 of 3.59 nM, and induces cell apoptosis. The combination of of ONO-4059 with doxorubicin, etoposide, vincristine or dexamethasone causes the increased apoptosis ratio.
| ALogP | 3.38 |
|---|---|
| Conteggio HBD | 1 |
| Legame rotabile | 5 |
| Pubchem Sid | 528766477 |
|---|---|
| Sorrisi canonici | C=CC(=O)N1CCCC(C1)N2C3=NC=NC(=C3N(C2=O)C4=CC=C(C=C4)OC5=CC=CC=C5)N |
| IUPAC Name | 6-amino-7-(4-phenoxyphenyl)-9-[(3S)-1-prop-2-enoylpiperidin-3-yl]purin-8-one |
| InChIKey | KSUDUUBCXJUFRL-SFHVURJKSA-N |
| INCHI | 1S/C25H24N6O3/c1-2-21(32)29-14-6-7-18(15-29)31-24-22(23(26)27-16-28-24)30(25(31)33)17-10-12-20(13-11-17)34-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)/t18-/m0/s1 |
| Isomeri SMILES | C=CC(=O)N1CCC[C@@H](C1)N2C3=NC=NC(=C3N(C2=O)C4=CC=C(C=C4)OC5=CC=CC=C5)N |
| PubChem CID | 89455219 |
| Peso molecolare | 456.5 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Classe | Benzene and substituted derivatives |
| Subclass | Diphenylethers |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Diphenylethers |
| Alternative Parents | Diarylethers Phenylimidazoles 6-aminopurines Purinones N-acylpiperidines Phenoxy compounds Phenol ethers Aminopyrimidines and derivatives N-substituted imidazoles Imidolactams Heteroaromatic compounds Tertiary carboxylic acid amides Acrylic acids and derivatives Ureas Amino acids and derivatives Azacyclic compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds Primary amines |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Diphenylether - Diaryl ether - 1-phenylimidazole - Purinone - 6-aminopurine - N-acyl-piperidine - Purine - Imidazopyrimidine - Phenoxy compound - Phenol ether - Aminopyrimidine - Imidolactam - Piperidine - Pyrimidine - N-substituted imidazole - Imidazole - Tertiary carboxylic acid amide - Acrylic acid or derivatives - Heteroaromatic compound - Azole - Amino acid or derivatives - Carboxamide group - Urea - Organoheterocyclic compound - Ether - Azacycle - Carboxylic acid derivative - Primary amine - Organic oxide - Organic oxygen compound - Carbonyl group - Hydrocarbon derivative - Organic nitrogen compound - Amine - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound |
| Descrizione | This compound belongs to the class of organic compounds known as diphenylethers. These are aromatic compounds containing two benzene rings linked to each other through an ether group. |
| External Descriptors | Not available |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Data | Oggetto |
|---|---|---|---|
 L2319324 | Certificate of Analysis | Sep 21, 2026 | O413862 |
| L2319325 | Certificate of Analysis | Sep 21, 2026 | O413862 |
| L2319326 | Certificate of Analysis | Sep 21, 2026 | O413862 |
| L2319370 | Certificate of Analysis | Sep 21, 2026 | O413862 |
| L2319371 | Certificate of Analysis | Sep 21, 2026 | O413862 |
| L2319482 | Certificate of Analysis | Sep 21, 2026 | O413862 |
| L2319327 | Certificate of Analysis | Dec 07, 2023 | O413862 |
| Solubilità | Solubility (25°C) In vitro DMSO: 20 mg/mL warmed with 50ºC Water: bath (43.81 mM); Ethanol: 3 mg/mL warmed with 50ºC Water: bath (6.57 mM); Water: Insoluble; |
|---|---|
| DMSO (mg/mL) Solubilità massima | 20 |
| DMSO (mM) Solubilità massima | 43.81161008 |
| Acqua (mg/mL) Solubilità massima | ＜1 |
| Peso molecolare | 456.500 g/mol |
| XLogP3 | 2.900 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 5 |
| Exact Mass | 456.191 Da |
| Monoisotopic Mass | 456.191 Da |
| Topological Polar Surface Area | 105.000 Ų |
| Heavy Atom Count | 34 |
| Formal Charge | 0 |
| Complexity | 751.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
