OP-1074 - ≥99% , CAS No.1443752-76-8

CAS: 1443752-76-8 Cat. No.: O650512 Molecular Weight: 457.56

GRADE & PURITY ≥99%

Storage

Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

Overview

OP-1074 is a pure antiestrogen and a selective ER degrader (PA-SERD) , shows specific antiestrogenic activity for ERα and ERβ , inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC 50 of 1.6 and 3.2 nM, respectively

In Vitro

OP-1074 (0-100 nM; 24 hours) inhibits  MCF-7 cells  and CAMA-1 cells proliferation with IC50 values of 6.3 and 9.2 nM, respectively. OP-1074 (100 nM; 24 hours) destabilizatizes ERα protein expression in MCF-7 and CAMA-1 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MCF-7 cells, CAMA-1 cells Concentration: 0 nM, 10 nM,100 nM Incubation Time: 24 hours Result: Inhibited breast cancer cell proliferation. Western Blot AnalysisCell Line: MCF-7 cells, CAMA-1 cells Concentration: 100 nM Incubation Time: 24 hours Result: Downregulated ERα protein expression.

Form:Solid

IC50& Target:ERα ERβ

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

OP-1074 is a pure antiestrogen and a selective ER degrader (PA-SERD) , shows specific antiestrogenic activity for ERα and ERβ , inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC 50 of 1.6 and 3.2u2009nM, respectively.

Storage

Store at -20°C, Argon charged, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

DEGRADER

Purity

≥99%

Names and Identifiers

• Molecular Weight: 457.56

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (218.55 mM; Need ultrasonic)