P7C3 - 10mM in DMSO , CAS No.301353-96-8

CAS: 301353-96-8 Cat. No.: P423107 Formula: C₂₁H₁₈Br₂N₂O Peso molecolare: 474.19 Numero EC: 685-988-7 PubChem CID: 2836187

GRADE & PURITY 10mM in DMSO

Synonyms

AKOS016344050 | SR-01000414355-1 | BCP09423 | DTXSID70385472 | SCHEMBL410147 | 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol | HY-15976 | J-017798 | 9H-CARBAZOLE-9-ETHANOL, 3,6-DIBROMO-.ALPHA.-((PHENYLAMINO)METHYL)- | 1-(3,6-Dibromo-carbazol

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

 Product Application：

P7C3 is an aminopropyl carbazole agent with proneurogenic and neuroprotective properties in newborn neural precursor cells of the dentate gyrus. Its analogs may be used in neurodegenerative disease research to study the process of neurogenesis in brain regions such as the subgranular zone of the hippocampal dentate gyrus. P7C3 and its analogs may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as potential drug for the treatment of condition such as Alzheimer′s disease, Parkinson′s disease, amyotrophic lateral sclerosis and traumatic brain injury.

Specifications

Sinonimi

AKOS016344050 | SR-01000414355-1 | BCP09423 | DTXSID70385472 | SCHEMBL410147 | 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol | HY-15976 | J-017798 | 9H-CARBAZOLE-9-ETHANOL, 3,6-DIBROMO-.ALPHA.-((PHENYLAMINO)METHYL)- | 1-(3,6-Dibromo-carbazol

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Pro-neurogenic and neuroprotective compound. Blocks apoptosis of newborn neurons of the dentate gyrus. Also protects mature neurons. Enhances neurogenesis and additionally improves cognitive behaviour. Blood-brain barrier permeable. Active in vivo .

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

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Nomi e identificatori

• Pubchem Sid: 528766525
• Sorrisi canonici: C1=CC=C(C=C1)NCC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)O
• IUPAC Name: 1-anilino-3-(3,6-dibromocarbazol-9-yl)propan-2-ol
• InChIKey: FZHHRERIIVOATI-UHFFFAOYSA-N
• INCHI: 1S/C21H18Br2N2O/c22-14-6-8-20-18(10-14)19-11-15(23)7-9-21(19)25(20)13-17(26)12-24-16-4-2-1-3-5-16/h1-11,17,24,26H,12-13H2
• Isomeri SMILES: C1=CC=C(C=C1)NCC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)O
• PubChem CID: 2836187
• Peso molecolare: 474.19

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Biphenyls and derivatives
        • Level5 Brominated biphenyls
          • Level6 Polybrominated biphenyls

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Biphenyls and derivatives
• Intermediate Tree Nodes: Brominated biphenyls
• Direct Parent: Polybrominated biphenyls
• Alternative Parents: Carbazoles N-alkylindoles Indoles Phenylalkylamines Aniline and substituted anilines Secondary alkylarylamines Substituted pyrroles Aryl bromides Heteroaromatic compounds Secondary alcohols 1,2-aminoalcohols Azacyclic compounds Organopnictogen compounds Organobromides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Polybrominated biphenyl - Carbazole - N-alkylindole - Indole - Indole or derivatives - Phenylalkylamine - Aniline or substituted anilines - Secondary aliphatic/aromatic amine - Aryl bromide - Substituted pyrrole - Aryl halide - Heteroaromatic compound - Pyrrole - Secondary alcohol - 1,2-aminoalcohol - Azacycle - Organoheterocyclic compound - Secondary amine - Organopnictogen compound - Organobromide - Organohalogen compound - Alcohol - Organonitrogen compound - Organic nitrogen compound - Organooxygen compound - Organic oxygen compound - Amine - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as polybrominated biphenyls. These are organic aromatic compounds containing a biphenyl moiety, which is substituted at two or more ring positions by a bromine atom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Meccanismi d'azione

Proprietà chimiche e fisiche

• Peso molecolare: 474.200 g/mol
• XLogP3: 5.700
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 473.977 Da
• Monoisotopic Mass: 471.979 Da
• Topological Polar Surface Area: 37.200 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 433.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1