Pam2CSK4 TFA, CAS No.868247-72-7(free base)

CAS: 868247-72-7(free base) Cat. No.: P288184 Formula: C₆₅H₁₂₆N₁₀O₁₂S.xC₂HF₃O₂ Peso molecolare: 1271.82 (free base)

GRADE & PURITY Moligand™, ≥95%

Panoramica

Il Pam2CSK4 (TFA), un lipopeptide, è un ligando e agonista TLR6-indipendente del TLR2. Il Pam2CSK4 (TFA) promuove l'aggregazione piastrinica e aumenta l'adesione delle piastrine alle superfici rivestite di collagene in modo dipendente dal TLR2/NF-κB/BTK. Il Pam2CSK4 (TFA) attiva anche l'espressione di iNOS e la produzione di NO nei macrofagi di topo

Specifications

Product Name

Pam2CSK4 TFA, CAS No.868247-72-7(free base)

Grado

Moligand™

Specifiche e purezza

Moligand™, ≥95%

Meccanismi biochimici e fisiologici

Agonista del recettore Toll-like 2/6 (TLR2/6). Induce la produzione di TNF-α in cellule mononucleari umane. Induce anche la proliferazione e l'attivazione delle cellule B spleniche di topo.

Sequenza

CSKKKK(Modifications: Cys =S-[2,3-Bis(palmitoyloxy)-(2-R)-propyl]-Cys)

Tipo di azione

AGONIST

CAS

868247-72-7(free base)

Tipo di molecola

Piccola molecola

Stoccaggio e spedizione

Condizioni di conservazione di stoccaggio

Al riparo dalla luce, conservare a -20°C

Spedito in

Cassetta del ghiaccio + cuscini per il ghiaccio

Obiettivi associati (umani)

TLR2 Tchem Toll-like receptor 2 (2 Activities)

Discover Target: TLR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

THP-1 (11052 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TLR2 Tchem Toll-like receptor 2 (975 Activities)

Discover Target: TLR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Obiettivi associati (non umani)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAW264.7 (28094 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione

Informazioni genetiche

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