Paromomicina solfato - ≥94% (HPLC) , CAS No.1263-89-4

CAS: 1263-89-4 Cat. No.: P160753 Formula: C₂₃H₄₅N₅O₁₄·xH₂SO₄ Peso molecolare: 615.63 (free base basis) Numero EC: 215-031-7

GRADE & PURITY ≥94%(HPLC)

Synonyms

SCHEMBL3355 | EN300-245883 | PAROMOMYCIN SULFATE [USP MONOGRAPH] | A883521 | PAROMOMYCIN SULFATE (USP-RS) | Paromomycin sulfate [USP:JAN] | (1,1'-BIPHENYL-2-YL)BORONIC ACID | Humagel | Q27269495 | Aminosidine sulphate | CHEBI:7935 | NSC227228 | D-Streptam

Storage

Room temperature

Shipped In

Normale

Panoramica

Applicazione del prodotto: sale di paromomicina solfato

Il sale di paromomicina solfato è stato utilizzato come composto di riferimento per l'attività antileishmaniana, come ligando che lega l'RNA e interagisce con l'aptamer. Questa interazione impedisce il legame (e il taglio) del dicer al duplex di RNA. È stato utilizzato anche in applicazioni di colture cellulari a 100 mg/l. La paromomicina inibisce le fasi di iniziazione e allungamento della sintesi proteica legandosi all'RNA ribosomiale 16S. La paramomicina si lega al sito A, causando la produzione di catene polipeptidiche difettose e portando alla morte cellulare.

Specifications

Sinonimi

SCHEMBL3355 | EN300-245883 | PAROMOMYCIN SULFATE [USP MONOGRAPH] | A883521 | PAROMOMYCIN SULFATE (USP-RS) | Paromomycin sulfate [USP:JAN] | (1,1'-BIPHENYL-2-YL)BORONIC ACID | Humagel | Q27269495 | Aminosidine sulphate | CHEBI:7935 | NSC227228 | D-Streptam

Specifiche e purezza

≥94% (HPLC)

Meccanismi biochimici e fisiologici

Antibiotico aminoglicoside ad ampio spettro. Inibitore della sintesi proteica. Si lega all'RNA ribosomiale 16S. Attivo per via orale.

Condizioni di conservazione di stoccaggio

Room temperature

Spedito in

Normale

Nota

Per quanto possibile, si consiglia di preparare e utilizzare le soluzioni lo stesso giorno. Tuttavia, se è necessario preparare in anticipo le soluzioni di riserva, si consiglia di conservarle in aliquote in fiale ben chiuse a -20°C. In genere, queste possono essere utilizzate per un mese. In genere, queste soluzioni sono utilizzabili fino a un mese. Prima dell'uso e dell'apertura della fiala, si consiglia di lasciare che il prodotto si equilibri a temperatura ambiente per almeno 1 ora. Avete bisogno di ulteriori consigli su solubilità, uso e manipolazione? Per ulteriori informazioni, visitare la pagina delle domande frequenti (FAQ).

Purezza

≥94%(HPLC)

Nomi e identificatori

• Pubchem Sid: 488189782
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488189782
• Sorrisi canonici: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
• IUPAC Name: (2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,5S)-5-[(1R,2R,3S,5R,6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric acid
• InChIKey: LJRDOKAZOAKLDU-UDXJMMFXSA-N
• INCHI: 1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
• Isomeri SMILES: C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
• RTECS: WK2320000
• CAS alternativo: 7542-37-2；84420-34-8
• Peso molecolare: 615.63 (free base basis)

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Classe Organooxygen compounds
      • Subclass Carbohydrates and carbohydrate conjugates
        • Level5 Aminosaccharides
          • Level6 Aminoglycosides
            • Level7 Aminocyclitol glycosides
              • Level8 2-deoxystreptamine aminoglycosides
                • Level9 4,5-disubstituted 2-deoxystreptamines

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Classe: Organooxygen compounds
• Subclass: Carbohydrates and carbohydrate conjugates
• Intermediate Tree Nodes: Aminosaccharides - Aminoglycosides - Aminocyclitol glycosides - 2-deoxystreptamine aminoglycosides
• Direct Parent: 4,5-disubstituted 2-deoxystreptamines
• Alternative Parents: Disaccharides O-glycosyl compounds Aminocyclitols and derivatives Cyclohexanols Cyclohexylamines Organic sulfuric acids Oxanes Tetrahydrofurans 1,2-aminoalcohols Acetals Oxacyclic compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Primary alcohols Organopnictogen compounds
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: 4,5-disubstituted 2-deoxystreptamine - Disaccharide - Glycosyl compound - O-glycosyl compound - Aminocyclitol or derivatives - Cyclohexanol - Cyclohexylamine - Sulfuric acid - Cyclitol or derivatives - Oxane - Cyclic alcohol - Tetrahydrofuran - Organic sulfuric acid or derivatives - Secondary alcohol - 1,2-aminoalcohol - Acetal - Organoheterocyclic compound - Oxacycle - Alcohol - Primary aliphatic amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic nitrogen compound - Amine - Organonitrogen compound - Primary amine - Primary alcohol - Aliphatic heteromonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as 4,5-disubstituted 2-deoxystreptamines. These are 2-deoxystreptamine aminoglycosides that a glycosidically linked to a pyranose of furanose unit at the C4- and C5-positions.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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HEK293 (82097 Activities)

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PCDH15 Tbio Protocadherin-15 (27 Activities)

Discover Target: PCDH15

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

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RPSA Tbio 80S Ribosome (239 Activities)

Discover Target: RPSA

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Escherichia coli (133304 Activities)

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Bacillus subtilis (32866 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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Bacillus spizizenii (1898 Activities)

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Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: Solubility in water: Completely soluble
• Sensibilità: Moisture sensitive
• Rotazione specifica [α]: 48° (C=1,H2O)
• Peso molecolare: 713.700 g/mol
• Hydrogen Bond Donor Count: 15
• Hydrogen Bond Acceptor Count: 23
• Rotatable Bond Count: 9
• Exact Mass: 713.264 Da
• Monoisotopic Mass: 713.264 Da
• Topological Polar Surface Area: 430.000 Ų
• Heavy Atom Count: 47
• Formal Charge: 0
• Complexity: 952.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 19
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Riferimenti

1. Lu Qi, Shanshan Liu, Zhen Yan, Min Qiao, Haonan Peng, Liping Ding.  (2023)  A cross-reactive fluorescent ensemble based on perylene derivative/surfactant assemblies for discrimination of multiple aminoglycoside antibiotics in aqueous solution.  JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY,      [PMID:] [10.1016/j.jphotochem.2023.115128]

2. Qiang Chen, Yiyan Cheng, Zhihong Huang, Shuo Du, Quanqian Lyu, Senbin Chen, Juan Tao, Lianbin Zhang, Jintao Zhu.  (2025)  All Drug Glassy Microneedle Patches for Instantaneous Transdermal Delivery.  ADVANCED MATERIALS,      [PMID:40960233] [10.1002/adma.202512849]