PEPA - ≥98% , CAS No.141286-78-4

CAS: 141286-78-4 Cat. No.: P335717 Molecular Weight: 402.44 PubChem CID: 6603828
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Synonyms
2,6-Difluoro-4-[2-(phenylsulfonylamino)ethylthio]phenoxyacetamide | J-007478 | Lopac-D-8941 | NCGC00094134-02 | AI3-05522 | 8S4PR7A8JS | 4-(2-(phenylsulfonylamino)ethylthio)-2,6-difluorophenoxyacetamide | CCG-204884 | DTXSID60424960 | HMS3262O22 | SR-0100
Storage
Room temperature
Shipped In
Normal
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
10mg
P335717-10mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$174.90
50mg
P335717-50mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$867.90
Enter a quantity for the sizes you want to add.
🧪

Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Room temperature Ships Normal Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 27 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

PEPA is an allosteric potentiator of AMPA desensitization. PEPA decreases the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by Glu with splic variant and subunit selectivity. PEPA enhances post-ischemic memory impairment in rats post i.v. administration. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4. PEPA is an activator of GluR.

Specifications

Synonyms
2, 6-Difluoro-4-[2-(phenylsulfonylamino)ethylthio]phenoxyacetamide | J-007478 | Lopac-D-8941 | NCGC00094134-02 | AI3-05522 | 8S4PR7A8JS | 4-(2-(phenylsulfonylamino)ethylthio)-2, 6-difluorophenoxyacetamide | CCG-204884 | DTXSID60424960 | HMS3262O22 | SR-0100
Specifications & Purity
≥98%
Storage
Room temperature
Shipped In
Normal
Action Type
ACTIVATOR
Purity
≥98%
Product Properties
pKapKₐ: 10.44 (Predicted)
Names and Identifiers
Canonical SmilesC1=CC=C(C=C1)S(=O)(=O)NCCSC2=CC(=C(C(=C2)F)OCC(=O)N)F
IUPAC Name2-[4-[2-(benzenesulfonamido)ethylsulfanyl]-2,6-difluorophenoxy]acetamide
InChIKeyGTACSIONMHMRPD-UHFFFAOYSA-N
INCHI1S/C16H16F2N2O4S2/c17-13-8-11(9-14(18)16(13)24-10-15(19)21)25-7-6-20-26(22,23)12-4-2-1-3-5-12/h1-5,8-9,20H,6-7,10H2,(H2,19,21)
Isomeric SMILES C1=CC=C(C=C1)S(=O)(=O)NCCSC2=CC(=C(C(=C2)F)OCC(=O)N)F
WGK Germany 3
PubChem CID 6603828
Molecular Weight 402.44

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClassBenzene and substituted derivatives
SubclassBenzenesulfonamides
Intermediate Tree Nodes Not available
Direct ParentBenzenesulfonamides
Alternative Parents Benzenesulfonyl compounds  Thiophenol ethers  Phenol ethers  Phenoxy compounds  Alkylarylthioethers  Fluorobenzenes  Alkyl aryl ethers  Organosulfonamides  Aryl fluorides  Aminosulfonyl compounds  Primary carboxylic acid amides  Sulfenyl compounds  Organonitrogen compounds  Organofluorides  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents Benzenesulfonamide - Benzenesulfonyl group - Phenoxy compound - Aryl thioether - Phenol ether - Thiophenol ether - Alkyl aryl ether - Alkylarylthioether - Halobenzene - Fluorobenzene - Aryl fluoride - Aryl halide - Organosulfonic acid amide - Aminosulfonyl compound - Organic sulfonic acid or derivatives - Sulfonyl - Organosulfonic acid or derivatives - Primary carboxylic acid amide - Carboxamide group - Sulfenyl compound - Carboxylic acid derivative - Ether - Thioether - Organosulfur compound - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organohalogen compound - Organofluoride - Organonitrogen compound - Organooxygen compound - Aromatic homomonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIA3 Tclin Glutamate receptor ionotropic, AMPA 3 (127 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIA1 Tclin Glutamate receptor ionotropic, AMPA 1 (277 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SH-SY5Y (11521 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATXN2 Tbio Ataxin-2 (54410 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIA3 Tclin Glutamate receptor AMPA 2/3 (11 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Gria4 Glutamate receptor ionotropic, AMPA 4 (112 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
nfo Endonuclease 4 (425 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NS1 Nonstructural protein 1 (33327 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gria2 Glutamate receptor AMPA 1/2 (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gria2 Glutamate receptor ionotropic, AMPA 2/3 (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
SolubilitySoluble in DMSO (100 mM), and ethanol (25 mM).
Refractive Indexn20D1.62 (Predicted)
Boil Point(°C)~617.6° C at 760 mmHg (Predicted)
Melt Point(°C)240.99° C (Predicted)
Molecular Weight402.400 g/mol
XLogP32.200
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Exact Mass402.052 Da
Monoisotopic Mass402.052 Da
Topological Polar Surface Area132.000 Ų
Heavy Atom Count26
Formal Charge0
Complexity541.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Zhu Sining, Wan Haitao, Yan Zhibo, Xi Chen, Zhang Yuzhuo, Zhang Fan.  (2023)  Synthesis and characterization of epoxy resin-based ion-imprinted polymer for selective removal of copper ions.  KOREAN JOURNAL OF CHEMICAL ENGINEERING,  40  (9): (2356-2364).  [PMID:] [10.1007/s11814-023-1468-1]
2. Hua Zhou, Liangdong Ye, Dongming Chen, Ziwei Li, Shanrong Li, Dacheng Li, Zhiyi Huang, Zhouqiao Wei, Shaorong Lu.  (2023)  A bio-based compatibilizer for improved interfacial compatibility in thermally conductive and electrically insulating graphite/high density poly(ethylene) composites.  JOURNAL OF VINYL & ADDITIVE TECHNOLOGY,  29  (6): (991-1001).  [PMID:] [10.1002/vnl.21977]
3. Sining Zhu, Chen Xi, Yuzhuo Zhang, Fan Zhang.  (2022)  Preparation and Characterization of Cadmium(II)-Ion-Imprinted Composites Based on Epoxy Resin.  ACS Applied Polymer Materials,      [PMID:] [10.1021/acsapm.2c01547]
4. Yufei Liu, Yikai Zhan, Min He, Chengjun Xiao, Shan Liu, Shuhao Qin, Jie Yu.  (2022)  Amino-functionalized carbon fiber/polyamide 6 composites with enhanced interfacial and mechanical properties.  Journal of Materials Research and Technology-JMR&T,      [PMID:] [10.1016/j.jmrt.2022.08.112]
5. Xiaofei Yan, Jie Fang, Jianjun Gu, Chenkai Zhu, Dongming Qi.  (2022)  Flame Retardancy, Thermal and Mechanical Properties of Novel Intumescent Flame Retardant/MXene/Poly(Vinyl Alcohol) Nanocomposites.  Nanomaterials,  12  (3): (477).  [PMID:35159825] [10.3390/nano12030477]
6. Qian Wang, Huanshun Yin, Jia Ding, Yunlei Zhou, Shiyun Ai.  (2021)  WS2/Bi/BiOBr Nanostructures for Photoelectrochemical Sensing of 5-Formyluracil-2′-deoxyuridine-5′-triphosphate through Hemin/G-Quadruplex Double Signal Amplification.  ACS Applied Nano Materials,      [PMID:] [10.1021/acsanm.1c01585]
7. Tianqi Chen, Mengjin Chen, Zhan Chen, Chaoyang Fu.  (2021)  Comprehensive investigation of modified polyethyleneimine as an efficient polymeric corrosion inhibitor in neutral medium: Synthesis, experimental and theoretical assessments.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2021.116803]
8. Hongyang Wang, Shuai Lan, Yu Zhang, Lu Zhang, Dandan Jia, Weiguo Zhang, Chun Liu, Lei Cao, Dongjun Wang.  (2021)  Unique Property of Nontraditional Intrinsic Luminescence in the Transforming of Solution-Hydrogel-Solid and Its Applications.  MACROMOLECULAR CHEMISTRY AND PHYSICS,  222  (13): (2100070).  [PMID:] [10.1002/macp.202100070]
9. Li Lao, Kuo Liu, Li Ren, Jinhong Yu, Jingzhen Cheng, Yuqi Li, Shaorong Lu.  (2021)  Improving Corrosion Protection and Friction Resistance of Q235 Steel by Combining Noncovalent Action and Rotating Coating Method.  ACS Omega,      [PMID:33778256] [10.1021/acsomega.0c05866]
10. Binglin Wang, Jiaxin Li, Xuejun Lai, Hongqiang Li, Yishen Chen, Xingrong Zeng.  (2021)  Synthesis of a novel N-alkoxyamine containing macromolecular intumescent flame retardant and its synergism in flame-retarding polypropylene.  POLYMERS FOR ADVANCED TECHNOLOGIES,  32  (6): (2452-2464).  [PMID:] [10.1002/pat.5275]
11. Gaofeng Zeng, Weiwei Zhang, Xin Zhang, Wenchao Zhang, Jianxin Du, Jiyu He, Rongjie Yang.  (2020)  Study on flame retardancy of APP/PEPA/MoO3 synergism in vinyl ester resins.  JOURNAL OF APPLIED POLYMER SCIENCE,  137  (35): (49026).  [PMID:] [10.1002/app.49026]
12. Yanchao Xu, Dongxue Guo, Tong Li, Yirong Xiao, Liguo Shen, Renjie Li, Yang Jiao, Hongjun Lin.  (2020)  Manipulating the mussel-inspired co-deposition of tannic acid and amine for fabrication of nanofiltration membranes with an enhanced separation performance.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:31931296] [10.1016/j.jcis.2020.01.004]
13. Xia Wang, Wulan Zeng, Hongyan Zhang, Dan Li, Hongjing Tian, Xiude Hu, Qian Wu, Chunling Xin, Xiaoyu Cao, Wenjing Liu.  (2019)  The dynamic CO2 adsorption of polyethylene polyamine-loaded MCM-41 before and after methoxypolyethylene glycol codispersion.  RSC Advances,  (46): (27050-27059).  [PMID:35528601] [10.1039/C9RA05404A]
14. Yuyuan Chen, Zhenzhen Wang, Xiaoli Hao, Fenglan Li, Yanjie Zheng, Jianzhong Zhang, Xinhua Lin, Shaohuang Weng.  (2019)  Selective and sensitive fluorescent monitoring of acid phosphatase (ACP) activity under neutral conditions through the ACP enzymatic catalysis of dopamine as a new substrate to polydopamine.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2019.126784]
15. Jianzhong Zhang, Yuyuan Chen, Zongfu Zheng, Zhenzhen Wang, Yanjie Zheng, Xinhua Lin, Shaohuang Weng.  (2019)  Fluorescence sensing of tyrosinase activity based on amine rich carbon dots through direct interaction in a homogeneous system: detection mechanism and application.  RSC Advances,  (35): (20029-20034).  [PMID:35514717] [10.1039/C9RA03098K]
16. Fan-Ning Meng, Meng-Qian Zhang, Kai Ding, Ting Zhang, Yong-Kuan Gong.  (2018)  Cell membrane mimetic PVDF microfiltration membrane with enhanced antifouling and separation performance for oil/water mixtures.  Journal of Materials Chemistry A,  (7): (3231-3241).  [PMID:] [10.1039/C7TA10135J]
17. Jing Xiong, Xue-dong Wu, Qun-ji Xue.  (2013)  One-step synthesis of highly monodisperse silver nanoparticles using poly-amino compounds.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2013.08.061]
18. Chengsheng Gui, Xiaoqing Liu, Di Wu, Tuo Zhou, Guyue Wang, Jin Zhu.  (2012)  Preparation of a New Type of Polyamidoamine and Its Application for Soy Flour-Based Adhesives.  JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY,  90  (2): (265-272).  [PMID:] [10.1007/s11746-012-2160-5]
19. Xia Wang, Wulan Zeng, Peidan Hu, Shengxin Liu, Yuechao Lin, Zhaowen He, Chunling Xin, Xiangjun Kong, Jinghan Xu.  (2024)  Effect of Additives on CO2 Adsorption of Polyethylene Polyamine-Loaded MCM-41.  MOLECULES,  29  (5): (1006).  [PMID:38474518] [10.3390/molecules29051006]
20. Wanyi Zhang, Chenyu Zhou, Junshu Wang, Hanbo Wang, Xingguang Su.  (2025)  Ratiometric fluorescence/colorimetric dual-mode detection of tertiary butylhydroquinone in edible oils based on copper‑cerium oxide nanozyme and nitrogen-doped carbon dots.  FOOD CHEMISTRY,      [PMID:40020619] [10.1016/j.foodchem.2025.143517]
21. Mingshan Jiang, Chengfu Han, Zhongyang Cao, Yi Zhao, Xinxin Zhao, Kangkang Zhou, Wei Zhai, Guoqiang Zheng, Xiaobo Zhu, Pengbo Wan, Kun Dai, Chuntai Liu, Changyu Shen.  (2025)  Microcrack-Structured Visualizable Hydrogel Sensor for Machine Learning-Assisted Handwriting Recognition.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202512316]
22. Zexian Chen, Yaojie Zhang, Wenjuan Dong, Yang Liu, Li Zhang, Yueping Dong, Zihan Wang, Yihong Chen, Qin Hu, Chuan Dong, Xiaojuan Gong.  (2025)  Lignin-derived carbon dots as a fluorescence and smartphone auxiliary sensing platform for the detection of Co(II) and VB12.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:41038481] [10.1016/j.ijbiomac.2025.148034]
23. Min Chen, Wen Wu, Yuyuan Chen, Qingqing Pan, Yongzhong Chen, Zongfu Zheng, Yanjie Zheng, Liying Huang, Shaohuang Weng.  (2018)  A fluorescent sensor constructed from nitrogen-doped carbon nanodots (N-CDs) for pH detection in synovial fluid and urea determination.  RSC Advances,  (72): (41432-41438).  [PMID:35559313] [10.1039/C8RA08406H]
24. Jiangyong Li, Qin Li, Qian Yang, Qi Tang, Xiaoyi Hu, Qing Liu, Liangke Zhang.  (2024)  A highly permeable nanoplatform based on functionalized carbon dots for synergistic reactive oxygen/nitrogen species tumor therapy.  Materials Today Nano,      [PMID:] [10.1016/j.mtnano.2024.100532]
25. Hao Sun, Xiaobing Li.  (2024)  Enhanced demulsification of alkaline-surfactant-polymer flooding O/W emulsion by multibranched polyether-polyquaternium based on the size effect of oil droplets.  CHEMOSPHERE,      [PMID:38969221] [10.1016/j.chemosphere.2024.142768]
26. Sheng Zhao, Feng Feng, Yuanting Chen, Xiaoyang Huang, Zhenzhen Wang, Chenfang Miao, Shaohuang Weng, Mingrui Lin.  (2025)  Simple detection of minocycline using the designed fluorine-doped carbon dots as probe through fluorescence approach.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.115068]
27. Xiao Shi, Honghao Jiao, Boxiao Zhao, Zhongjun Li, Haibiao Yu, Junshuo Cui, Ying Xiong.  (2026)  Achieving ultra-high concentration CNT dispersion by cationic perylene bisimide-based dispersant.  COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING,      [PMID:] [10.1016/j.compositesa.2026.109754]
Solution Calculators
Reviews

Customer Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.