Peretinoin - 10mM in DMSO , CAS No.81485-25-8

CAS: 81485-25-8 Cat. No.: P654548 Formula: C₂₀H₃₀O₂ Peso molecolare: 302.45 Numero EC: 632-866-6

QUALITÀ & PUREZZA 10mM in DMSO

Storage

Protected from light,Argon charged,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression . Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC 50 of 9 μM .

In Vitro

Peretinoin (10-40?μM; 12-72?hours) exhibits suppressed SPHK1 expression after 24?h treatment, even at 10?μM and more prominent after 72 h peretinoin treatment. Peretinoin? (5?μM; 24?hours) up-regulates the expression of LC3B-II and increases autophagy flux in mouse primary hepatocytes. ? MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Autophagy AssayCell Line: Mouse primary hepatocytes (MPH) and the human HCC HepG2 cell line Concentration: 5 μM Incubation Time: 24 hours Result: Up-regulated the expression of LC3B-II and increased autophagy flux. Western Blot AnalysisCell Line: Human hepatoma (Huh-7) cells Concentration: 10, 20 and 40 μM Incubation Time: 12, 24, 48 and 72  hours Result: Exhibited suppressed SPHK1 expression after 24 h treatment, even at 10 μM.

Specifiche

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR) . Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro

Condizioni di conservazione di stoccaggio

Protected from light,Argon charged,Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Nomi e identificatori

Isomeri SMILES

CC(=CCC/C(=C/CC/C(=C/C=C/C(=C/C(=O)O)/C)/C)/C)C

CAS alternativo

81485-25-8

Termini MeSH

(2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid;(2E,4E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,4,6,10,14-pentaenoic acid;3,7,11,15-tetramethylhexadeca-2,4,6,10,14-pentaenoic acid;NIK-333;peretinoin

Peso molecolare

302.45

Domande frequenti

How should this product be stored?

Store at ?80 °C, protected from light, under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 81485-25-8, the molecular formula is C20H30O2, and the molecular weight is 302.45 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.