PF-04979064 - 10mM in DMSO , CAS No.1220699-06-8

CAS: 1220699-06-8 Cat. No.: P654992 Formula: C₂₄H₂₆N₆O₃ Peso molecolare: 446.5 Numero EC: 808-374-4 PubChem CID: 46866705

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

PF-04979064 is a potent and selective PI3K / mTOR dual kinase inhibitor with K i s of 0.13 nM and 1.42 nM for PI3Kα and mTOR , respectively.

In Vitro

PF-04979064 is tested against human class I PI3K isoforms PI3Kα, PI3Kγ, and PI3Kδ, with PI3Kα K i of 0.13 nM, PI3Kγ K i of 0.111 nM, and PI3Kδ K i of 0.122 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PF-04979064 is progressed to rat in vivo PK studies and exhibits robust PK profile: Vdss=5.23 L/kg, Cl=19.3 mL/min/kg, T 1/2 =1.85 h, and F%=61% . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:PI3Kα 0.13 nM (Ki) PI3Kγ 0.111 nM (Ki) PI3Kδ 0.122 nM (Ki) mTOR 1.42 nM (Ki)

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

PF-04979064 is a potent and selective PI3K / mTOR dual kinase inhibitor with K i s of 0.13 nM and 1.42 nM for PI3Kα and mTOR , respectively.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Nomi e identificatori

• Isomeri SMILES: CC1=NC=C(C=C1)C2=NC3=C4C(=CN=C3C=C2)N(C(=O)N4C5CCN(CC5)C(=O)[C@H](C)O)C
• PubChem CID: 46866705
• Peso molecolare: 446.5

Obiettivi associati (umani)

PIK3CG Tclin Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (1 Activities)

Discover Target: PIK3CG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIK3CA Tclin Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (2 Activities)

Discover Target: PIK3CA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIK3CD Tclin Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (1 Activities)

Discover Target: PIK3CD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MTOR Tclin Serine/threonine-protein kinase mTOR (2 Activities)

Discover Target: MTOR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)