10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Panoramica
PF-05198007 is a potent, orally active and selective arylsulfonamide Na v 1.7 inhibitor. PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771
In Vitro
PF-05198007 (30 nM) blocks on average 83.0 ± 2.7% of the total TTX-S current indicating that the major TTX-S conductance is carried through Na v 1.7 channels in small-diameter mouse DRG neurons (n = 35). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
PF-05198007 (1 or 10 mg/kg, orally) reduces the capsaicin flare response in WT, but not Na v 1.7Na v 1.8Cre mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult Male C57Bl/6J Wild type (WT) and Na v 1.7Na v 1.8Cre mice . Dosage: 1 or 10 mg/kg. Administration: Orally once. Result: Reduced the flare response to capsaicin for the duration of the observation period (55 mins; Vehicle; 4930 ± 751 versus 1 and 10 mg/kg 1967 ± 472 and 2265 ± 382, respectively (n = 7), AUC, p < 0.05).
IC50& Target:Nav1.7
Specifications
Specifiche e purezza
10mM in DMSO
Meccanismi biochimici e fisiologici
PF-05198007 is a potent, orally active and selective arylsulfonamide Na v 1.7 inhibitor. PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771.
Condizioni di conservazione di stoccaggio
Store at -80°C
Spedito in
Dry ice packs + Cold packs
Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.
Tipo di azione
INHIBITOR
Nomi e identificatori
Peso molecolare
533.91
Documentazione
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
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Recensioni
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Domande frequenti
How should this product be stored?
Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 1235406-19-5, the molecular formula is C19H12ClF4N5O3S2, and the molecular weight is 533.91 g/mol.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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