PF-CBP1 HCl - ≥96% , CAS No.2070014-93-4

CAS: 2070014-93-4 Cat. No.: P413931 Formula: C₂₉H₃₇ClN₄O₃ Peso molecolare: 525.08 PubChem CID: 119081416

GRADE & PURITY ≥96%

Synonyms

4-(2-(5-(3,5-dimethylisoxazol-4-yl)-2-(4-propoxyphenethyl)-1H-benzo[d]imidazol-1-yl)ethyl)morpholine hydrochloride | 5-(Dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]-1H-1,3-benzodiazole hydrochloride

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

Information

PF-CBP1 HCl PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP) .It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.

Targets

CREBBP (Cell-free assay); p300/CBP (Cell-free assay) 125nM; 363nM

In vitro

PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 down regulates RGS4 in neurons, a target linked to Parkinson\'s disease.It is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC.PF-CBP1 is also a potent inhibitor of EP300 and possesses no cytotoxicity in macrophages, and hepatotoxicity in cell-based models as long as the concentration is not very high.

Cell Research(from reference)

Cell lines：mouse J774 macrophage-like cell line 

Concentrations：0.1-10\xa0μM 

Incubation Time：30min 

Specifications

Sinonimi

4-(2-(5-(3,5-dimethylisoxazol-4-yl)-2-(4-propoxyphenethyl)-1H-benzo[d]imidazol-1-yl)ethyl)morpholine hydrochloride | 5-(Dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]-1H-1,3-benzodiazole hydrochloride

Specifiche e purezza

≥96%

Meccanismi biochimici e fisiologici

PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Purezza

≥96%

Nomi e identificatori

• Pubchem Sid: 504772912
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504772912
• Sorrisi canonici: CCCOC1=CC=C(C=C1)CCC2=NC3=C(N2CCN4CCOCC4)C=CC(=C3)C5=C(ON=C5C)C.Cl
• IUPAC Name: 4-[2-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[2-(4-propoxyphenyl)ethyl]benzimidazol-1-yl]ethyl]morpholine;hydrochloride
• InChIKey: HFOZCHHWLMTUTP-UHFFFAOYSA-N
• INCHI: 1S/C29H36N4O3.ClH/c1-4-17-35-25-9-5-23(6-10-25)7-12-28-30-26-20-24(29-21(2)31-36-22(29)3)8-11-27(26)33(28)14-13-32-15-18-34-19-16-32;/h5-6,8-11,20H,4,7,12-19H2,1-3H3;1H
• PubChem CID: 119081416
• Peso molecolare: 525.08

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 100 mg/mL (190.44 mM); Ethanol: 100 mg/mL (190.44 mM); Water: Insoluble
• Sensibilità: Moisture sensitive.
• Peso molecolare: 525.100 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 10
• Exact Mass: 524.255 Da
• Monoisotopic Mass: 524.255 Da
• Topological Polar Surface Area: 65.600 Ų
• Heavy Atom Count: 37
• Formal Charge: 0
• Complexity: 654.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Domande frequenti

What is the purity of this product?

This product is supplied at ≥96% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2070014-93-4, the molecular formula is C29H37ClN4O3, and the molecular weight is 525.08 g/mol. InChIKey HFOZCHHWLMTUTP-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.