Phalloidin Amine, TFA salt - BioReagent,Biological Stain,for fluorescence analysis,for microscopy,≥95% , CAS No.87876-22-0 (free)

CAS: 87876-22-0 (free) Cat. No.: A1521155 Formula: C₃₅H₄₉N₉O₁₀S (free) Peso molecolare: 787.88 (free)

GRADE & PURITY BioReagent, Biological Stain, for Fluorescence analysis, for Microscopy, ≥95%

Synonyms

((R)-4-Hydroxy-4-methyl-Orn⁷)-Phalloidin, TFA salt | ((R)-4-Hydroxy-4-methyl-Orn⁷)-Phalloidin | Amino Phalloidin | Phalloidin Amine

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Application

Cell Staining, Fluorescence Analysis

Panoramica

Phalloidin is a bicyclic heptapeptide toxin that binds specifically to the interface between Factin subunits, locking adjacent subunits together. Compared with actin monomers, phalloidin binds much more strongly to actin filaments. It stabilizes actin filaments by decreasing the rate constant for dissociation of actin subunits from filament ends, thereby effectively inhibiting filament depolymerization. In addition, studies have shown that phalloidin can also inhibit the ATP hydrolytic activity of Factin. The toxin stabilizes the Factin structure by trapping actin monomers in a conformation distinct from that of Gactin and greatly reducing the monomer dissociation rate constant associated with ADP trapping.

The cellular effects of phalloidin are concentrationdependent. At low concentrations, it recruits weakly polymerized actin and filamin in the cytoplasm to form stable actin polymer “islands” without disturbing the structure of stress fibers (i.e., thick bundles of microfilaments). This property makes it an important tool for studying the distribution of Factin: fluorescently labeled phalloidin derivatives can stain actin filaments for optical microscopy. Fluorescent phalloidin derivatives enable precise localization of actin filaments in both live and fixed cells, and can also be used for the visualization of single actin filaments in vitro, serving as a key tool for highresolution studies of actin networks.

Product Advantages

High binding specificity: Selectively binds polymeric Factin (fibrous actin) with little to no binding to monomeric Gactin, resulting in a high signaltonoise ratio.

Specifications

Sinonimi

((R)-4-Hydroxy-4-methyl-Orn⁷)-Phalloidin, TFA salt | ((R)-4-Hydroxy-4-methyl-Orn⁷)-Phalloidin | Amino Phalloidin | Phalloidin Amine

Specifiche e purezza

BioReagent,Biological Stain,for fluorescence analysis,for microscopy,≥95%

Stabilità e conservazione

Store at -20℃ long term (24 months). Store in the dark.

Condizioni di conservazione di stoccaggio

Protected from light,Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Biological Stain, BioReagent, per l'analisi a fluorescenza, per la microscopia

Purezza

≥95%

Product Line

biological_products

Nomi e identificatori

Peso molecolare

787.88 (free)

Proprietà chimiche e fisiche

• Solubilità: Soluble in DMSO/H₂O
• Sensibilità: Light-sensitive

Domande frequenti

What is the purity of this product?

This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What does Biological Stain mean?

Biological Stain indicates that the product has been processed and tested for biological and biochemical applications. Specifications may include endotoxin limits, microbial controls, sterility, low DNase/RNase/protease activity, and verified biological activity where relevant.

What does BioReagent mean?

BioReagent indicates that the product has been processed and tested for biological and biochemical applications. Specifications may include endotoxin limits, microbial controls, sterility, low DNase/RNase/protease activity, and verified biological activity where relevant.

How should this product be stored?

Store at ?20 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 87876-22-0 (free).

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.