Fenformina cloridrato - ≥97% , CAS No.834-28-6

CAS: 834-28-6 Cat. No.: P102146 Formula: C₁₀H₁₅N₅ · HCl Peso molecolare: 241.72 Numero EC: 212-637-3

GRADE & PURITY ≥97%

Synonyms

1-Phenethylbiguanide hydrochloride | Phenethylbiguanide hydrochloride | Phenformin (hydrochloride) | Phenformin.HCl | Dipar | USAF VI-6 | Meltrol | 834-28-6 | Phenformin HCl | Meltrol-50 | 1-(Diaminomethylidene)-2-(2-phenylethyl)guanidine hydrochloride |

Storage

Conservare a -20°C, con carica di argon

Shipped In

Cassetta del ghiaccio + cuscini per il ghiaccio

Panoramica

La fenformina cloridrato è un agente antidiabetico della classe delle biguanidi, in grado di attivare l'attività dell'AMPK

Specifications

Sinonimi

1-Phenethylbiguanide hydrochloride | Phenethylbiguanide hydrochloride | Phenformin (hydrochloride) | Phenformin.HCl | Dipar | USAF VI-6 | Meltrol | 834-28-6 | Phenformin HCl | Meltrol-50 | 1-(Diaminomethylidene)-2-(2-phenylethyl)guanidine hydrochloride |

Specifiche e purezza

≥97%

Meccanismi biochimici e fisiologici

Attiva l'AMPK, aumentandone l'attività e la fosforilazione. Effetti antitumorali. Attivo in vivo.

Condizioni di conservazione di stoccaggio

Conservare a -20°C, con carica di argon

Spedito in

Cassetta del ghiaccio + cuscini per il ghiaccio

Nota

Per quanto possibile, si consiglia di preparare e utilizzare le soluzioni lo stesso giorno. Tuttavia, se è necessario preparare in anticipo le soluzioni di riserva, si consiglia di conservarle in aliquote in fiale ben chiuse a -20°C. In genere, queste possono essere utilizzate per un mese. In genere, queste soluzioni sono utilizzabili fino a un mese. Prima dell'uso e dell'apertura della fiala, si consiglia di lasciare che il prodotto si equilibri a temperatura ambiente per almeno 1 ora. Avete bisogno di ulteriori consigli su solubilità, uso e manipolazione? Per ulteriori informazioni, visitare la pagina delle domande frequenti (FAQ).

Purezza

≥97%

Nomi e identificatori

Pubchem Sid

488181825

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488181825

Sorrisi canonici

C1=CC=C(C=C1)CCN=C(N)N=C(N)N.Cl

IUPAC Name

1-(diaminomethylidene)-2-(2-phenylethyl)guanidine;hydrochloride

InChIKey

YSUCWSWKRIOILX-UHFFFAOYSA-N

INCHI

1S/C10H15N5.ClH/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8;/h1-5H,6-7H2,(H6,11,12,13,14,15);1H

Isomeri SMILES

C1=CC=C(C=C1)CCN=C(N)N=C(N)N.Cl

WGK Germania

3

RTECS

DU2200000

Numero UN

2811

Gruppo di imballaggio

I

Peso molecolare

241.72

Reaxy-Rn

35474258

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=35474258&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Classe Organonitrogen compounds
      • Subclass Guanidines

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Classe: Organonitrogen compounds
• Subclass: Guanidines
• Intermediate Tree Nodes: Not available
• Direct Parent: Biguanides
• Alternative Parents: Benzene and substituted derivatives Propargyl-type 1,3-dipolar organic compounds Carboximidamides Organopnictogen compounds Imines Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Biguanide - Benzenoid - Monocyclic benzene moiety - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidamide - Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Imine - Aromatic homomonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as biguanides. These are organic compounds containing two N-linked guanidines.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

Discover Target: TSHR

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PPARA Tclin Peroxisome proliferator-activated receptor alpha (9197 Activities)

Discover Target: PPARA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)

Discover Target: THRB

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CXCL8 Tchem Interleukin-8 (642 Activities)

Discover Target: CXCL8

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Lymphoblastoid cell (5959 Activities)

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HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)

Discover Target: HIF1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

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SMN1 Tchem Survival motor neuron protein (34246 Activities)

Discover Target: SMN1

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LMNA Tbio Prelamin-A/C (36751 Activities)

Discover Target: LMNA

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CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

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IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)

Discover Target: IDH1

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Obiettivi associati (non umani)

Plasmodium falciparum (966862 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

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Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 Activities)

Discover Target: Nr1i2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Meccanismi d'azione

Proprietà chimiche e fisiche

• Sensibilità: Hygroscopic
• Peso molecolare: 241.720 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 241.109 Da
• Monoisotopic Mass: 241.109 Da
• Topological Polar Surface Area: 103.000 Ų
• Heavy Atom Count: 16
• Formal Charge: 0
• Complexity: 236.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Domande frequenti

What is the purity of this product?

This product is supplied at ≥97% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 834-28-6, the molecular formula is C10H15N5 · HCl, and the molecular weight is 241.72 g/mol. InChIKey YSUCWSWKRIOILX-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.